ArticleNeurosciences (Riyadh, Saudi Arabia)2026
Alterations in Gut Microbiota and their Association with Intestinal Mucosal Injury in Children with Febrile Seizures.
Article in Neurosciences (Riyadh, Saudi Arabia), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To explore the correlation between diversity of the gut microbiota and key markers of inflammation and intestinal mucosal injury in pediatric febrile seizures (FS). Methods: This study compared 15 FS children (FS group) and 15 healthy individuals (normal control group). The participants underwent 16S rDNA sequencing to analyze gut microbiota profiles. ELISA was employed to measure peripheral blood concentrations of the pro-inflammatory cytokines TNF-α and IL-6, as well as intestinal mucosal injury indicators such as endotoxin (BT), D-lactate (D-Lac), and diamine oxidase (DAO). Analysis assessed the correlation between gut microbiota composition, inflammatory factors, and indicators of intestinal mucosal damage in FS. Results: Analysis of the FS group revealed a distinct gut microbiota profile compared to the control group, with notable variations in abundance at the phylum level. A marked decrease in the abundance of Patescibacteria was observed in the FS group. LEfSe clustering tree analysis revealed enrichment of Bacteroides in the FS group, suggesting an association with FS. Serum levels of IL-6, TNF-α, BT, D-Lac, and DAO in children with FS were higher than those in controls, (P<0.05). A Spearman analysis found that the altered microbiota of the FS group was correlated with increased expression of IL-6, BT, D-Lac, and DAO (P<0.05). Conclusion: Children with FS have disrupted gut microbiota, and this dysbiosis is correlated with inflammation and intestinal mucosal damage.
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