ArticleJADA foundational science2022
Proton pump inhibitors are associated with reduced periodontal disease severity.
Article in JADA foundational science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- The oral‒gut axis in periodontal disease: a systematic review of the associated human evidence of its mechanisms and implications for patient care.Journal of oral microbiology · 2026Review
- Impact of proton pump inhibitors on periodontal health - A systematic review.The Saudi dental journal · 2024Review
- The influence of proton pump inhibitors on tissue attachment around teeth and dental implants: A scoping review.Clinical and experimental dental research · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Proton pump inhibitors (PPIs), such as omeprazole, esomeprazole, and pantoprazole, are frequently prescribed to treat acid-related gastrointestinal diseases. PPIs inhibit the hydrogen potassium-adenosine triphosphatase proton pump in gastric parietal cells, decreasing acid release. However, PPIs also affect bone metabolism by altering mineralization and resorption rates and inducing changes in the gastrointestinal microbiota. Therefore, the authors assessed whether PPIs also might be associated with periodontal pathogenesis. Methods: Medical and dental records (N = 1,017) of patients seeking treatment at the School of Dental Medicine at the State University of New York, University at Buffalo Postgraduate Periodontics Clinic (2010-2017) were reviewed to obtain periodontal status, medication history, systemic diseases and conditions, and demographic information. Patients who received a diagnosis of generalized periodontitis stages III through IV, grades B through C were further assessed in this study (n = 518). Results: A statistically significant inverse relationship was found between the use of PPIs and the percentage of teeth with 6 mm or greater probing depths. That relationship persisted after adjusting for diabetes, smoking, and the presence of systemic factors. The prevalence of pocket depths 6 mm or greater was 13.1% in patients taking PPIs vs 19.9% in patients not taking PPIs (group difference, 6.8%; 34.2% decrease; 95% CI, 2.1% to 11.6%; Conclusions: The use of PPIs is associated with less severe periodontal disease.
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