ArticleJADA foundational science2022
Silver diamine fluoride alters microbial communities in subsurface dentin.
Article in JADA foundational science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07741409 (Povidone Iodine to Prevent Early Childhood Caries), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Povidone Iodine to Prevent Early Childhood Caries
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Potential of Silver Diamine Fluoride in Non-Operative Management of Dental Caries in Primary Teeth: A Systematic Review.Medicina (Kaunas, Lithuania) · 2024Pooled it
- Mapping the oral microbiome in children with oral diseases using next-generation sequencing: a systematic review.Journal of oral microbiology · 2026Review
- Evaluation of the Efficacy of 3.8% Silver Diamine Fluoride and Papacarie as Root Canal Irrigants in Smear Layer Removal in Young Permanent Teeth: AnInternational journal of clinical pediatric dentistry · 2025Article
- Silver diamine fluoride differentially affects dentin and hypomineralized enamel permeabilities.Dental materials : official publication of the Academy of Dental Materials · 2025Article
- Dental caries shallow-layer microbe harvest and data display method shows taxa pre-harvest spatial positions, absolute and relative abundance and diversity related to lesion pulpal depth.Journal of oral microbiology · 2025Article
Corrections and comments
- Erratum issuedCorrection.2024
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Silver diamine fluoride (SDF) is a dental biomaterial with cariostatic properties that are thought to be owing to, in part, to its antimicrobial activity. This study examines the mechanisms by which SDF may impact the oral microbiota. Methods: This case-control study uses samples from carious lesions of primary teeth with or without SDF treatment; the authors used microbial viability testing and next-generation sequencing to compare untreated or SDF-treated carious surface biofilm and subsurface carious dentin. Results: Viability testing of surface biofilm from carious lesions with or without SDF treatment visualized by confocal laser scanning microscopy revealed no change in microbial viability several weeks after SDF treatment. Microbial community composition of carious surface biofilm before and after SDF treatment was determined using Conclusions: Although SDF does not significantly alter the carious surface biofilm microbial community composition, it promotes a shift in community membership deeper within dentin tubules, representing a previously unrecognized mechanism of action for SDF in caries arrest.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.