ArticleFrontiers in immunology2026
Evaluation of kidney stone-related renal infection status by 18F-FDG PET/CT in lung cancer patients with concomitant nephrolithiasis: a multicenter study.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Positron emission tomography/computed tomography (PET/CT) has demonstrated significant clinical utility in the localization of infectious foci, yet its application in nephrolithiasis-associated renal infections remains underexplored. Methods: This retrospective cohort study assessed the diagnostic efficacy of Results: Clinically, PET/CT detected focal FDG uptake in 77 patients (64.2%), demonstrating 85.7% sensitivity and 76.7% specificity for infection identification. SUVmax positively correlated with stone burden and proinflammatory cytokines. The larger the size of the stone, the more severe the kidney infection, which in turn further aggravated the development of the stone. Furthermore, preclinical micro-PET/CT in CaOx mice revealed spatial concordance between crystal deposition and metabolic activity, paralleling human cytokine trends. Discussion: In lung cancer patients with concomitant nephrolithiasis,
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