Evidence map›Paper›PMID 42238473›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Geographical Variation in Antimalarial Drug Resistance Marker Prevalence Across the Southern African Elimination Eight Region.

Jaishree Raman, Andrés Aranda-Díaz, Maxwell Mabona, Mukosha Chisenga, Maria Florinda João, Domingos Jandondo, Pedro Rafael Dimbu, Nomcebo Nhlengethwa, Sabelo V Dlamini, Lydia Eloff and 34 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

44 authors.

Jaishree RamanLaboratory for Antimalarial Resistance Monitoring and Malaria Operational Research, Centre of Emerging Zoonotic and Parasitic Diseases, National Institute for Communicable Diseases, Johannesburg, South Africa.ORCID 0000-0003-0728-3093
Andrés Aranda-DíazEPPIcenter Research Program, Department of Medicine, University of California, San Francisco, United States of America.ORCID 0000-0002-0566-4901
Maxwell MabonaLaboratory for Antimalarial Resistance Monitoring and Malaria Operational Research, Centre of Emerging Zoonotic and Parasitic Diseases, National Institute for Communicable Diseases, Johannesburg, South Africa.ORCID 0000-0003-0701-589X
Mukosha ChisengaSADC Malaria Elimination Eight Secretariat, Windhoek, Namibia.
Maria Florinda JoãoPrograma Nacional do Controlo da Malária, Luanda, Angola.
Domingos JandondoInstituto Nacional de Investigação em Saúde, Luanda, Angola.
Pedro Rafael DimbuPrograma Nacional do Controlo da Malária, Luanda, Angola.
Nomcebo NhlengethwaNational Malaria Programme, Manzini, Eswatini.
Sabelo V DlaminiDepartment of Environmental Health Sciences, University of Eswatini, Mbabane, Eswatini.
Lydia EloffDepartment of Biochemistry, Microbiology, and Biotechnology, School of Science, University of Namibia, Windhoek, Namibia.ORCID 0009-0007-3766-2138
Stark KatokeleNational Vector-Borne Disease Control Program, Ministry of Health and Social Services, Windhoek, Namibia.
Davis R MumbengegwiMalaria Operational Research Program, Multidisciplinary Research Services, University of Namibia, Windhoek, Namibia.
Qedusizi NyawoKwaZulu-Natal Provincial Malaria Control Program, Jozini, KwaZulu-Natal, South Africa.
Mbavhalelo ShandukaniNational Department of Health, Pretoria, South Africa.
Sydney MwanzaNational Health Research and Training Institute, Ndola, Zambia.
Moonga HawelaNational Malaria Elimination Centre, Ministry of Health, Lusaka, Zambia.
Simone BoeneISGlobal, Barcelona, Spain.ORCID 0000-0002-8323-9863
Arlindo ChidimatembueCentro de Investigação em Saúde de Manhiça, Manhiça, Mozambique.ORCID 0000-0003-0549-9894
Bernardete RafaelPrograma Nacional do Controlo da Malária, Maputo, Mozambique.
Eduard Rovira-VallbonaISGlobal, Barcelona, Spain.ORCID 0000-0002-4765-1076
Brighton MangenaSADC Malaria Elimination Eight Secretariat, Windhoek, Namibia.
Sonja B LauterbachLaboratory for Antimalarial Resistance Monitoring and Malaria Operational Research, Centre of Emerging Zoonotic and Parasitic Diseases, National Institute for Communicable Diseases, Johannesburg, South Africa.ORCID 0000-0003-4941-9972
Takalani I MakhanthisaLaboratory for Antimalarial Resistance Monitoring and Malaria Operational Research, Centre of Emerging Zoonotic and Parasitic Diseases, National Institute for Communicable Diseases, Johannesburg, South Africa.ORCID 0000-0002-6044-3669
Hazel GwarindaLaboratory for Antimalarial Resistance Monitoring and Malaria Operational Research, Centre of Emerging Zoonotic and Parasitic Diseases, National Institute for Communicable Diseases, Johannesburg, South Africa.ORCID 0000-0002-8605-7870
Blaženka D LetinićLaboratory for Antimalarial Resistance Monitoring and Malaria Operational Research, Centre of Emerging Zoonotic and Parasitic Diseases, National Institute for Communicable Diseases, Johannesburg, South Africa.
Faith De AmaralEPPIcenter Research Program, Department of Medicine, University of California, San Francisco, United States of America.ORCID 0000-0002-5583-7671
Isobel RoutledgeMalaria Elimination Initiative, Global Health Group, University of California, San Francisco, United States of America.ORCID 0000-0002-0354-4076
Beatriz Arregui-GallegoISGlobal, Barcelona, Spain.ORCID 0000-0002-3735-6735
Mishalan MoodleySequencing Core Facility, National Institute for Communicable Diseases, Johannesburg, South Africa.ORCID 0000-0002-2501-6880
Jonathan FeatherstoneSequencing Core Facility, National Institute for Communicable Diseases, Johannesburg, South Africa.
Power B TshikaeKwaZulu-Natal Provincial Malaria Control Program, Jozini, KwaZulu-Natal, South Africa.
Arshad IsmailSequencing Core Facility, National Institute for Communicable Diseases, Johannesburg, South Africa.ORCID 0000-0003-4672-5915
Jose Franco MartinsPrograma Nacional do Controlo da Malária, Luanda, Angola.
Quinton DlaminiNational Malaria Programme, Manzini, Eswatini.
Baltazar CandrinhoPrograma Nacional do Controlo da Malária, Maputo, Mozambique.
Petrina UusikuNational Vector-Borne Disease Control Program, Ministry of Health and Social Services, Windhoek, Namibia.
Ednah BaloyiNational Department of Health, Pretoria, South Africa.
Busiku HamainzaNational Malaria Elimination Centre, Ministry of Health, Lusaka, Zambia.
Alfredo MayorISGlobal, Barcelona, Spain.ORCID 0000-0003-3890-2897
Bryan GreenhouseEPPIcenter Research Program, Department of Medicine, University of California, San Francisco, United States of America.ORCID 0000-0003-0287-9111
Amy WesolowskiDepartment of Epidemiology Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States of America.ORCID 0000-0001-6320-3575
Chadwick SikaalaSADC Malaria Elimination Eight Secretariat, Windhoek, Namibia.
John ChimumbwaSADC Malaria Elimination Eight Secretariat, Windhoek, Namibia.
Jennifer L SmithMalaria Elimination Initiative, Global Health Group, University of California, San Francisco, United States of America.

Funding

Data and analysis ecosystem for eukaryotic pathogen targeted sequencingU01AI184646 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GREENHOUSE, BRYAN R · 2024 to 2025
$1.5M
Genetic and social network analysis to target interventions for malaria eliminationK01AI153555 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SMITH, JENNIFER LINNEA · 2020 to 2024
$725k
Bill & Melinda Gates Foundation INV-019032Bill & Melinda Gates Foundation INV-024346Bill & Melinda Gates Foundation INV-031512NIAID NIH HHS K01 AI153555NIAID NIH HHS U01 AI184646
6 · The paper itself

Abstract

Global efforts to control and eliminate malaria are threatened by the emergence and spread of antimalarial drug resistance. The World Health Organization recommends surveillance of molecular markers of resistance as a complementary approach to therapeutic efficacy studies. Here, we report the first regional analysis of malaria drug resistance markers from genomic surveillance across six southern African countries spanning diverse transmission intensities and geographies. Dried blood spots, collected from rapid diagnostic test-positive individuals in Angola, Eswatini, Namibia, and Zambia in 2023, Mozambique in 2022, and South Africa between 2022 and 2024 using a standardized collection method, were analyzed using a

Indexed as

Angolaartemisinin partial resistanceEswatinikelch13malariaMozambiqueNamibiaregional genomic surveillanceSouth Africasouthern AfricaZambia

Identifiers

PMID42238473
PMCPMC13228783

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.