ArticlemedRxiv : the preprint server for health sciences2026
A clinically integrated, frameless human Neuropixels workflow.
Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
High-density electrophysiological recording with Neuropixels probes enables single-unit resolution of human neural activity, but integration into routine clinical environments remains challenging and reported recordings have been limited to a few US centres. Here, we present a reproducible roadmap for human Neuropixels recordings under a nationally managed regulatory framework in the United Kingdom. Guided by the IDEAL Stage 2a (Development) framework, we established a frameless intraoperative workflow using manufacturer-sterilised probes and a commercially available, clinical-grade setup. We prospectively evaluated this workflow in six participants (mean age 62.5 years) undergoing elective ventriculoperitoneal shunt surgery, assessed across three predefined endpoints: clinical safety, procedural timing, and neural data yield. Iterative failure-mitigation cycles resolved key technical barriers, including neuronavigation interference and hardware instability. The workflow achieved zero research-related adverse events, maintained a 30-minute procedural extension, and progressively increased single-unit yield to 146 manually curated units.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.