Evidence map›Paper›PMID 42238423›Full record

ArticlemedRxiv : the preprint server for health sciences2026

CNS-selective plasma p-tau217 accurately captures Alzheimer's disease pathology and progression.

Xuemei Zeng, Marissa F Farinas, Michel N Nafash, Denis S Smirnov, Brian J Lopresti, Cristy Matan, Dana L Tudorascu, Sarah B Berman, Robert A Sweet, C Elizabeth Shaaban and 11 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Xuemei ZengDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Marissa F FarinasDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Michel N NafashDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0009-0005-6953-075X
Denis S SmirnovDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Brian J LoprestiDepartment of Radiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Cristy MatanDepartment of Radiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Dana L TudorascuDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Sarah B BermanAlzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA.
Robert A SweetDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
C Elizabeth ShaabanAlzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA.ORCID 0000-0002-3016-1951
Beth E SnitzAlzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA.
Julia K KoflerAlzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA.
Neelesh K NadkarniAlzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA.
Howard J AizensteinDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Milos D IkonomovicDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Tharick A PascoalDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Victor L VillemagneDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
M Ilyas KambohAlzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA.
Ann D CohenDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Oscar L LopezAlzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA.
Thomas K KarikariDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0003-1422-4358

Funding

Vascular Moderators of the Impact of Alzheimer's Pathology in the Young-OldP01AG025204 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HOWARD J AIZENSTEIN, Ann D. Cohen · 2005 to 2026
$56.5M
Longitudinal multicenter head-to-head harmonization of tau PET tracersR01AG073267 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BAKER, SUZANNE L, PASCOAL, THARICK · 2021 to 2025
$41.1M
TAU, AB, SYNUCLEIN AND NITRATIVE/OXIDATIVE DAMAGE IN MCIP01AG014449 · NIA · UNIVERSITY OF PITTSBURGH · PI MUFSON, ELLIOTT JAY · 1997 to 2024
$39.7M
Research Education ComponentP30AG066468 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI C. Elizabeth Shaaban · 2020 to 2026
$29.4M
Mild Cognitive Impairment: A Prospective Community StudyR37AG023651 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Carmen Andreescu, MARY GANGULI · 2021 to 2026
$18.2M
Plasma brain-derived tau: a novel Alzheimer’s disease-type neurodegeneration biomarker with potential to complete the AT(N) scheme in bloodR01AG083874 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Thomas K Karikari · 2023 to 2026
$14.5M
The RAW Brain - The Effect of Rumination, Anxiety and Worry on Aging and Dementia RiskR01MH108509 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Carmen Andreescu · 2016 to 2026
$10.6M
Predictors of Altered CNS Structure, Function, and Connectomics in the Elderly using a Health Disparities FrameworkR01AG072641 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Ann D. Cohen · 2022 to 2026
$9.6M
Genetic Architecture of Alzheimer’s disease ProteinopathiesR01AG064877 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CRUCHAGA, CARLOS, KAMBOH, M. ILYAS · 2021 to 2024
$8.4M
Search for the Alzheimers GenesR01AG030653 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAMBOH, M. ILYAS · 2009 to 2019
$7.7M
Alzheimer Diagnosis in older Adults with Chronic Conditions ADACC NetworkU24AG082930 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Nicole R. Fowler, Thomas K Karikari · 2023 to 2026
$7.3M
Examining the Persistence of Neurocognitive Benefits of ExerciseR01AG083156 · NIA · ADVENTHEALTH ORLANDO · PI ERICKSON, KIRK I · 2023 to 2025
$6.8M
NIA NIH HHS P01 AG014449NIA NIH HHS P01 AG025204NIA NIH HHS P30 AG066468NIA NIH HHS R01 AG013672NIA NIH HHS R01 AG025516NIA NIH HHS R01 AG030653NIA NIH HHS R01 AG041718NIA NIH HHS R01 AG064877NIA NIH HHS R01 AG072641NIA NIH HHS R01 AG073267NIA NIH HHS R01 AG075336NIA NIH HHS R01 AG083156NIA NIH HHS R01 AG083874NIA NIH HHS R37 AG023651NIA NIH HHS RF1 AG077474NIA NIH HHS U24 AG082930NIMH NIH HHS R01 MH108509NINDS NIH HHS U01 NS131740NINDS NIH HHS U01 NS141777
6 · The paper itself

Abstract

Blood-based biomarkers have expanded access to biologically supported diagnosis of Alzheimer's disease (AD), particularly through measurement of amyloid-beta (Aβ) and phosphorylated tau species

Identifiers

PMID42238423
PMCPMC13228684

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.