Evidence map›Paper›PMID 42238417›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Defective B cell tolerance in SLE lymph nodes underpins VH

Caterina E Faliti, Midushi Ghimire, Melissa Garcia-Vega, Rachel C Watermeier, Amanda Callahan, Julia Burke, Olivia Posadas, Ashish K Mishra, Surender Khurana, Victor Greiff and 7 more

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Caterina E FalitiDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USA.ORCID 0000-0003-0487-1914
Midushi GhimireDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USA.
Melissa Garcia-VegaDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USA.ORCID 0000-0001-5902-4603
Rachel C WatermeierDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University, Atlanta, GA, USA.
Amanda CallahanDepartment of Microbiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL 35294, USA.
Julia BurkeDepartment of Microbiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL 35294, USA.
Olivia PosadasDivision of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Silver Spring, MD, USA.
Ashish K MishraDivision of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Silver Spring, MD, USA.
Surender KhuranaDivision of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Silver Spring, MD, USA.ORCID 0000-0002-0593-7965
Victor GreiffDepartment of Immunology, University of Oslo, Oslo University Hospital, Oslo, Norway.ORCID 0000-0003-2622-5032
Chris D ScharerDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0001-7716-8504
John M LindnerBioMed X Institute, Heidelberg, Germany.ORCID 0000-0002-4940-5354
R Glenn KingDepartment of Microbiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL 35294, USA.ORCID 0000-0001-6522-0053
Mary NewellDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA.ORCID 0000-0001-5521-2260
Arezou KhosroshahiDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USA.ORCID 0000-0001-8365-8497
F Eun-Hyung LeeDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University, Atlanta, GA, USA.ORCID 0000-0002-6133-5942
Iñaki SanzDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USA.ORCID 0000-0003-4182-587X

Funding

Regulation of B cell Responses in SLE and Other Autoimmune DiseasesU19AI110483 · NIAID · EMORY UNIVERSITY · PI JEREMY M. BOSS · 2014 to 2026
$76.6M
Regulation of Pathogenic Plasma Cells in Human SLEP01AI125180 · NIAID · EMORY UNIVERSITY · PI Ignacio E. Sanz · 2016 to 2026
$28.2M
Translational Research Project Effector and Regulatory B cells in SLEU19AI056390 · NIAID · UNIVERSITY OF ROCHESTER · PI MOSMANN, TIM R. · 2003 to 2013
$8.9M
Molecular Mechanisms of Human Long-lived Plasma Cell Generation in the Bone Marrow and SpleenU01AI141993 · NIAID · EMORY UNIVERSITY · PI Frances Eun-Hyung Lee · 2019 to 2026
$5.7M
Human Plasma Cell Maturation & Maintenance through CD138, TNFRSF, and Modulation of Ig SecretionR01AI172254 · NIAID · EMORY UNIVERSITY · PI Frances Eun-Hyung Lee · 2023 to 2026
$3.1M
NIAID NIH HHS P01 AI125180NIAID NIH HHS R01 AI172254NIAID NIH HHS U01 AI141993NIAID NIH HHS U19 AI056390NIAID NIH HHS U19 AI110483
6 · The paper itself

Abstract

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease driven by uncensored B and T cell autoreactivity. Understanding this pathogenic process has been hampered by lack of studies of secondary lymphoid organs in human SLE. Using minimally invasive lymph node fine needle aspirates (LN-FNAs), we profiled tissue-resident immune cells from 59 SLE patients and 34 healthy controls through high-dimensional 43-color flow cytometry, antigen-specific tetramer probing, and sc-RNA sequencing with paired VH/VL repertoire analysis. Our findings reveal hyperactive lymph node immunity in SLE characterized by spontaneous germinal center (GC) activation, plasma cell accumulation enriched in mature CD19

Identifiers

PMID42238417
PMCPMC13228782

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.