Evidence map›Paper›PMID 42238403›Full record

ArticlemedRxiv : the preprint server for health sciences2026

RAG-mediated structural variation and its impact on relapse risk in acute lymphoblastic leukemia.

Tanxin Liu, Yunqi Li, Charley Wang, Cassandra J Clark, Nathan Anderson, Erin Marcotte, Michael R Lieber, Srividya Swaminathan, Joseph L Wiemels, Logan G Spector and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Tanxin LiuCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90033, USA.
Yunqi LiCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90033, USA.
Charley WangCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90033, USA.
Cassandra J ClarkDivision of Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis, MN, 55454, USA.ORCID 0000-0002-5993-4540
Nathan AndersonDivision of Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis, MN, 55454, USA.
Erin MarcotteDivision of Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis, MN, 55454, USA.
Michael R LieberDepartments of Pathology, Biochemistry, Molecular Microbiology & Immunology, and Section of Molecular & Computational Biology (Department of Biological Sciences), University of Southern California, Los Angeles, CA, 90033, USA.
Srividya SwaminathanDepartment of Systems Biology, Beckman Research Institute of the City of Hope, Monrovia, CA, 91016, USA.
Joseph L WiemelsCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90033, USA.ORCID 0000-0003-4838-9951
Logan G SpectorDivision of Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis, MN, 55454, USA.ORCID 0000-0003-2516-0222
Vijay G SankaranDivision of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute, Boston, MA 02115.ORCID 0000-0003-0044-443X
Carol FriesDepartment of Pediatrics, Hematology and Oncology, University of Rochester, Rochester, NY, USA.
Adam J de SmithCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90033, USA.

Funding

NCTN BIQSFP ANBL1531 (NRT)U10CA180886 · NCI · PUBLIC HEALTH INSTITUTE · PI Douglas S. Hawkins · 2014 to 2026
$390.6M
COG FOREIGN ACCRUALU10CA098543 · NCI · NATIONAL CHILDHOOD CANCER FOUNDATION · PI ADAMSON, PETER C. · 2003 to 2013
$335.5M
COG SDMC - Statistics CoreU10CA180899 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TODD A ALONZO · 2014 to 2026
$132.8M
Children's Oncology Group Statistics &Data Center GrantU10CA098413 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI ANDERSON, JAMES R · 2003 to 2013
$67.5M
Understanding the Increased Risk of Childhood Acute Lymphoblastic Leukemia in LatinosR01CA262263 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Adam De Smith · 2022 to 2026
$3.4M
Variant to Function Mapping of B-ALL Risk LociR01CA292941 · NCI · BOSTON CHILDREN'S HOSPITAL · PI Adam De Smith, Vijay Ganesh Sankaran · 2024 to 2026
$2.0M
NCI NIH HHS R01 CA262263NCI NIH HHS R01 CA292941NCI NIH HHS U10 CA098413NCI NIH HHS U10 CA098543NCI NIH HHS U10 CA180886NCI NIH HHS U10 CA180899
6 · The paper itself

Abstract

Relapse during treatment of B-cell acute lymphoblastic leukemia (B-ALL) is a harbinger of poor outcomes. Identifying biomarkers for subsequent relapse risk which are detectable at B-ALL diagnosis remains a priority. Off-target recombination-activating gene (RAG)-mediated structural variants (SVs) generate genomic instability that drives leukemogenesis and may underlie treatment resistance. Leveraging sequencing data in 1,496 pediatric B-ALL patients enriched for relapse status (relapse n=532; non-relapse n=964), we characterized RAG-mediated SVs across B-ALL molecular subtypes and examined their association with patient characteristics and their impact on clinical outcomes. Off-target RAG-mediated SVs were overall frequent, particularly in

Identifiers

PMID42238403
PMCPMC13228792

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.