Evidence map›Paper›PMID 42238373›Full record

ArticleOsteoarthritis imaging2024

Quantification of macrophage activity in knee synovial tissue using [

Zachary J Koudys, Brent A Lanting, Garth Blackler, Joseph Daniel Klapak, Matthew Fox, C Thomas Appleton, Jonathan D Thiessen, Matthew G Teeter

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoarthritis imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Current Uses for Medical Imaging With Orthopaedic Implant Technology.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zachary J KoudysDepartment of Medical Biophysics, Schulich School of Medicine & Dentistry, Western University, London, Canada.
Brent A LantingDepartment of Surgery, Schulich School of Medicine & Dentistry, Western University, London, Canada.
Garth BlacklerDepartment of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, Canada.
Joseph Daniel KlapakDepartment of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, Canada.
Matthew FoxLawson Health Research Institute, London, Canada.
C Thomas AppletonDepartment of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, Canada.
Jonathan D ThiessenDepartment of Medical Biophysics, Schulich School of Medicine & Dentistry, Western University, London, Canada.
Matthew G TeeterDepartment of Medical Biophysics, Schulich School of Medicine & Dentistry, Western University, London, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Inflammation in knee osteoarthritis (OA) is mediated primarily by synovial tissue macrophages, but non-invasive measurement of macrophage activity in vivo is a challenge. Activated macrophages markedly increase expression of the translocator protein (TSPO). In the context of other diseases TSPO-PET using the [ Design: Ten participants with late-stage OA scheduled for knee replacement surgery were recruited. Prior to surgery, 5 of the participants underwent a clinical [

resultsThe autoradiography [ Conclusion: [

Indexed as

[18F]FEPPA PET/MRIActivated macrophagesInflammationOrthopedic imagingOsteoarthritisSynovitis

Identifiers

PMID42238373
PMCPMC13228735

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.