Evidence map›Paper›PMID 42238369›Full record

ArticleOsteoarthritis imaging2024

Association between progression of knee osteoarthritis pathology and gait changes over two years: Data from the IMI-APPROACH cohort.

Mylène P Jansen, Diana Hodgins, Simon C Mastbergen, Margreet Kloppenburg, Francisco J Blanco, Ida K Haugen, Francis Berenbaum, Felix Eckstein, Frank W Roemer, Wolfgang Wirth

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In one paragraph

Article in Osteoarthritis imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Mylène P JansenDepartment of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, the Netherlands.
Diana HodginsDynamic Metrics Limited, Codicote, United Kingdom.
Simon C MastbergenDepartment of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, the Netherlands.
Margreet KloppenburgDepartment of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands.
Francisco J BlancoGrupo de Investigación de Reumatología (GIR), INIBIC - Complejo Hospitalario Universitario de A Coruña, SERGAS. Centro de Investigación CICA, Departamento de Fisioterapia y Medicina, Universidad de A Coruña, A Coruña, Spain.
Ida K HaugenCenter for treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway.
Francis BerenbaumDepartment of Rheumatology, AP-HP Saint-Antoine Hospital, Paris, France.
Felix EcksteinInstitute of Imaging and Functional Musculoskeletal Research, Center of Anatomy and Cell Biology & Ludwig Boltzmann Institute for Arthritis and Rehabilitation (LBIAR), Paracelsus Medical University, Salzburg, Austria.
Frank W RoemerQuantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA, USA.
Wolfgang WirthInstitute of Imaging and Functional Musculoskeletal Research, Center of Anatomy and Cell Biology & Ludwig Boltzmann Institute for Arthritis and Rehabilitation (LBIAR), Paracelsus Medical University, Salzburg, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Gait alterations in knee osteoarthritis (OA) patients are potentially related to structural progression of joint tissues, of which some are modifiable. The current objective was to determine whether progression in individual OA pathologies is related to gait kinematic parameters in knee OA patients, and whether these changes are influenced by pain. Design: Range of motion (ROM) during gait, joint tissue pathologies and morphology from index knee radiographs and MRI, and WOMAC pain were collected at baseline and at two-years in the IMI-APPROACH clinical knee OA cohort. Principal component (PC) analysis was performed on two-year change in gait parameters; the resulting (first) PC was compared between progressors and non-progressors for each structural parameter. When the PC indicated differences between groups ( Results: 191 patients (age 66.5 ± 6.7; BMI 27.5 ± 4.8; 76 % female; 51 % Kellgren-Lawrence grade ≥2) were analyzed. The gait change PC differed between progressors and non-progressors for meniscal extrusion, bone marrow lesions (BMLs), and patellofemoral cartilage lesions. Further, meniscal extrusion progressors showed significantly more knee ROM and calf ROM decrease, BML progressors worsened more in thigh ROM, and patellofemoral cartilage lesion progressors improved in knee ROM. BML results were no longer significant after pain change adjustment ( Conclusions: Meniscal extrusion and BML progression are associated with gait worsening, though for BMLs the effect might be influenced by pain.

Indexed as

Bone marrow lesionGaitImagingKnee osteoarthritisMeniscal extrusionProgression

Identifiers

PMID42238369
PMCPMC13228702

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.