ArticleAsian journal of urology2026
Exploring the role of urinary brain-derived neurotrophic factor in diagnosis and follow-up of overactive bladder in women: A prospective analytical study in a tertiary care center experience.
Article in Asian journal of urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Overactive bladder (OAB) is a common clinical manifestation of voiding dysfunction. It is a symptom-based condition. A new, accurate, objective, and noninvasive test to diagnose OAB and assess therapeutic outcomes is lacking. The study aimed to assess the use of the urinary biomarker brain-derived neurotrophic factor (BDNF), as a non-invasive diagnostic and follow-up tool. Methods: This prospective analytical study was conducted in the Department of Urology, Cairo University Hospitals. A total of 96 women were included in the study and distributed into two groups: Group A with OAB ( Results: The mean urinary BDNF/creatinine ratio in the OAB group was 15.2 (standard deviation [SD] 5.9) pg/mg, ranging from 5.1 to 24.2 pg/mg, whereas the mean urinary BDNF/creatinine ratio in the control group was 5.6 (SD 2.7) pg/mg, ranging from 1.1 to 10.0 pg/mg, with a statistically significant difference between the groups (independent samples Conclusion: BDNF can be used to assess the presence of OAB and follow up the course of OAB as a supplementary tool to clinical assessment and urodynamics.
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