Observational studySaudi medical journal2026
Growing Evidence for Distinct Clinical Features and Early Diagnostic Age of Cutaneous T-Cell Lymphoma in Saudi Arabia:
Observational study in Saudi medical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: To examine trends in Cutaneous T-cell Lymphoma (CTCL) disease presentation in the Western Region of the Kingdom of Saudi Arabia (KSA). Cutaneous T-cell lymphomas (CTCLs) have heterogeneous clinical presentation, and disease characteristics can vary between regions and ethnic groups. Methods: We conducted a local observational study at the Princess Noorah Oncology Center and King Abdulaziz Medical City, Jeddah, with CTCL patients referred to and treated in the Saudi Arabian National Guard facilities from January 2017 to December 2023. Medical records of included patients were retrospectively reviewed. Main outcome measures were demographics and clinical characteristics. Results: The cohort comprised 69 CTCL patients. Mean (SD) age at diagnosis was 43.7 (15.6) years. Male patients outnumbered females by 1.38:1. The most frequently diagnosed form of CTCL was mycosis fungoides (MF), representing 72.5% of patients (50/69). Among MF patients, 87.8% had early-stage disease (stage IA-IIA), and the most common skin presentation was pigmented/erythematous patches (72.0%). Among CTCL lesions, 30.0% were hypopigmented and the mean (SD) diagnostic age in hypopigmented MF was 33.7 (16.4) years. Conclusion: CTCL presented at a relatively young age in Western KSA. We observed a high prevalence of hypopigmented MF and reported a young mean diagnostic age among hypopigmented MF patients. Our study highlighted the regional variation in CTCL presentation and the importance of investigating trends to facilitate diagnosis and treatment.
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