Evidence map›Paper›PMID 42238274›Full record

ArticleSaudi medical journal2026

Prognostic Significance of Lymphovascular Invasion in Breast Cancer: Insights From a Retrospective Analysis at a Tertiary Care Center.

Nora Trabulsi, Shayma Alotaibi, Mohammed Bahabri, Hussain A Alkhalifah, Ghady D Alshehri, Sultan K Alshali, Ali Farsi, Marwan Alhajeili, Hassan Al-Turki, Salma Sait and 3 more

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Article in Saudi medical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Nora TrabulsiDepartment of Surgery, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.ORCID 0000-0003-0540-922x
Shayma AlotaibiDepartment of General Surgery, King Abdulaziz Hospital, Jeddah, Saudi Arabia.
Mohammed BahabriFaculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Hussain A AlkhalifahFaculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Ghady D AlshehriDepartment of Neurosciences, King Faisal Specialist Hospital & Research Center, Jeddah, Saudi Arabia.
Sultan K AlshaliDepartment of Surgery, Saudi German Hospital, Jeddah, Saudi Arabia.
Ali FarsiDepartment of Surgery, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Marwan AlhajeiliDepartment of Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Hassan Al-TurkiDepartment of Surgery, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Salma SaitDepartment of Surgery, International Medical Center, Jeddah, Saudi Arabia.
Alaa ShabkahDepartment of Surgery, International Medical Center, Jeddah, Saudi Arabia.
Rana AjaboorDepartment of Anatomical Pathology, Faculty of Medicine, King Abdulaziz University Hospital, King Abdulaziz University, Jeddah, Saudi Arabia.
Hessa AljhdaliDepartment of Anatomical Pathology, Faculty of Medicine, King Abdulaziz University Hospital, King Abdulaziz University, Jeddah, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To explore the relationship between lymphovascular invasion (LVI) and outcomes across different histopathological subtypes, tumor grades, clinical stages, hormone receptor profiles, and treatment modalities. Lymphovascular invasion is a well-recognized histopathological feature associated with tumor dissemination in breast cancer. However, its prognostic weight is under-reported in Middle Eastern cohorts. Methods: We retrospectively reviewed data from 828 women treated for invasive breast carcinoma at King Abdulaziz University Hospital from 2010 to 2020. Clinicopathologic variables, treatments, and outcomes were extracted. Overall survival (OS) and event-free survival (EFS) were estimated and tested using Kaplan-Meier curves; independent predictors were identified with stepwise Cox models. Results: Lymphovascular invasion was identified in 31.5% of cases, and Kaplan-Meier analysis revealed significantly reduced mean OS (9.94 vs. 12.43 years; Conclusion: Our findings underscore LVI as a robust and independent prognostic factor for poor survival outcomes in breast cancer, with implications for multiple clinicopathologic and therapeutic contexts. These results support the routine incorporation of LVI into prognostic models and treatment algorithms in breast cancer management.

Indexed as

Breast NeoplasmsLymphatic MetastasisAdultAgedFemaleHumansKaplan-Meier EstimateMiddle AgedNeoplasm InvasivenessPrognosisRetrospective StudiesTertiary Care CentersBreast cancerEvent-free survivalLymphovascular invasionPrognosisSaudi Arabia

Identifiers

PMID42238274
PMCPMC13227373

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.