ArticleFrontiers in cardiovascular medicine2026
Conventional cardiac resynchronization therapy upgrading and its effect on functional mitral regurgitation in patients with pacing-induced cardiomyopathy.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Data on the effects of conventional cardiac resynchronization therapy (CRT) upgrading by implantation of a left ventricular lead via the coronary sinus on functional mitral regurgitation (MR) in patients with pacing-induced cardiomyopathy are scarce. Methods: This analysis of the UPGRADE study, an investigator-initiated randomized controlled trial to evaluate the effect of conventional CRT on central sleep apnea, evaluated the significance of CRT on MR in all included patients. Differences in all-cause mortality were assessed in patients with significant MR during long-term follow-up. Results: Overall, 54 patients were included in the trial. MR was found in the majority of patients [mild: Conclusion: Conventional CRT upgrading in patients with pacing-induced cardiomyopathy was associated with significant improvement in MR grading. The presence of moderate or severe MR at baseline was associated with impaired outcomes during long-term follow-up, suggesting that these patients represent a high-risk cohort.
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