Evidence map›Paper›PMID 42238257›Full record

ArticleJournal of the Endocrine Society2026

Targeted proteomics reveal association between maternal biomarkers and child body weight in the first year of life.

Noura Kabbani, Thomas Ebert, Holger Stepan, Massimiliano Lia, Matthias Blüher, Ronny Baber, Mandy Vogel, Ronald Biemann, Wieland Kiess, Anke Tönjes and 1 more

Abstract read
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In one paragraph

Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Noura KabbaniClinic and Polyclinic for Gynaecology, University of Leipzig Medical Center, Leipzig 04103, Germany.ORCID https://orcid.org/0009-0007-9387-3028
Thomas EbertMedical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig 04103, Germany.ORCID https://orcid.org/0000-0003-1683-9276
Holger StepanLeipzig Reproductive Health Research Center, Leipzig University, Leipzig 04103, Germany.ORCID https://orcid.org/0000-0003-1264-7365
Massimiliano LiaDepartment of Obstetrics, University of Leipzig Medical Center, Leipzig 04103, Germany.ORCID https://orcid.org/0000-0001-8285-3792
Matthias BlüherLeipzig Reproductive Health Research Center, Leipzig University, Leipzig 04103, Germany.ORCID https://orcid.org/0000-0003-0208-2065
Ronny BaberLeipzig Reproductive Health Research Center, Leipzig University, Leipzig 04103, Germany.ORCID https://orcid.org/0009-0004-2539-7849
Mandy VogelLeipzig Reproductive Health Research Center, Leipzig University, Leipzig 04103, Germany.ORCID https://orcid.org/0000-0003-2051-1249
Ronald BiemannInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig 04103, Germany.ORCID https://orcid.org/0000-0002-0820-8231
Wieland KiessLIFE Child, Hospital for Children and Adolescents, Department of Pediatrics, University of Leipzig Medical Center, Leipzig 04103, Germany.ORCID https://orcid.org/0000-0003-4118-9455
Anke TönjesMedical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig 04103, Germany.ORCID https://orcid.org/0009-0005-1944-1812
Susanne Schrey-PetersenDepartment of Obstetrics, University of Leipzig Medical Center, Leipzig 04103, Germany.ORCID https://orcid.org/0000-0002-8012-0998

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Context: The intrauterine environment strongly influences children's health and development. Distinct cardiovascular biomarkers have been linked to birth weight and later weight gain, with correlations observed in maternal and umbilical cord serum. Objective: To describe (1) maternal cardiovascular biomarker patterns during the second and third trimesters and (2) potential associations between these biomarkers and offspring weight at birth and at 1 year of age. Design: Within the LIFE Child Study, serum samples from 86 healthy mothers at 24 and 36 gestational weeks and cord blood at birth were analyzed using the Olink® Target 96 Cardiovascular III panel. Statistical analyses (Wilcoxon test, Spearman correlation, multivariate regression) were performed in R. Setting: Community-based cohort, Leipzig, Germany. Patients or Other Participants: Eighty-six mother-child pairs from the LIFE Child cohort. Mothers had no pregnancy complications, and all newborns had birth weights between 2500 and 4500 g. Main Outcome Measure: Offspring body weight at 1 year of age. Results: Of 92 maternal serum biomarkers, 88 were detectable. Seventy biomarkers increased significantly from 24 to 36 weeks ( Conclusion: In our cohort, maternal PON3 and ITGB2 were independently associated with early postnatal growth, potentially implicating these biomarkers in fetal programming.

Indexed as

biomarkerbirth weightfetal programmingITGB2olink proteomicsPON3

Identifiers

PMID42238257
PMCPMC13227062

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.