Evidence map›Paper›PMID 42238190›Full record

ArticleOsteoarthritis imaging2026

Associations between habitual walking speed and in vivo tibial cartilage strain in individuals with anterior cruciate ligament reconstruction.

Caroline Lisee, David Lalush, Cortney Armitano-Lago, Elizabeth Bjornsen, Jason R Franz, Jeffrey T Spang, Matthew E Dausch, Brian Pietrosimone

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Article in Osteoarthritis imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Caroline LiseeDepartment of Kinesiology, University of Georgia, 330 River Road, Athens, GA 30605, USA.
David LalushLampe Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, 10010 Mary Ellen Jones, Campus Box 7575, Chapel Hill, NC 27599, USA.
Cortney Armitano-LagoSchool of Medicine, University of North Carolina at Chapel Hill, Bondurant Hall, Campus Box 7120, Chapel Hill, NC 27599, USA.
Elizabeth BjornsenLampe Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, 10010 Mary Ellen Jones, Campus Box 7575, Chapel Hill, NC 27599, USA.
Jason R FranzLampe Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, 10010 Mary Ellen Jones, Campus Box 7575, Chapel Hill, NC 27599, USA.
Jeffrey T SpangDepartment of Orthopaedics, University of North Carolina at Chapel Hill, 130 Mason Farm Road, Campus Box 7055, Chapel Hill, NC 27599, USA.
Matthew E DauschLampe Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, 10010 Mary Ellen Jones, Campus Box 7575, Chapel Hill, NC 27599, USA.
Brian PietrosimoneDepartment of Orthopaedics, University of North Carolina at Chapel Hill, 130 Mason Farm Road, Campus Box 7055, Chapel Hill, NC 27599, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: The purpose of the study was to determine associations between habitual walking speed and an in vivo magnetic resonance imagining (MRI) measure of tibial cartilage strain following primary anterior cruciate ligament reconstruction (ACLR). Methods: Habitual walking speed was collected over ground in 12 individuals (5 Males/7 Females). Participants underwent an MRI of their ACLR knee to capture resting tibial articular cartilage thickness. Following the MRI, participants walked on a treadmill at their habitual walking speed for 3000 steps. Cartilage thickness was calculated for pre-loading and post-loading across the entire articulating surface and strain maps were created by calculating the change in thickness from pre- to post-loading thickness. Average cartilage strain was calculated in 6 evenly divided regions of interest (ROI) of the medial and lateral tibial cartilage. Spearman's rank correlations and 95 % confidence intervals (CIs) (ρ) were used to assess associations between habitual walking speed and average tibial articular cartilage strain in each ROI. Results: Slower habitual walking speed was moderately associated with greater strain in medial central inner tibial cartilage region (ρ=-0.67, Conclusion: Our study demonstrates a measurable in vivo link between slower habitual walking speeds and greater cartilage strain, which provides further rationale for evaluating the mechanistic link between modifying habitual walking speed to influence important biophysical changes in cartilage health.

Indexed as

Anterior cruciate ligament reconstructionCartilage, articularKnee InjuriesMagnetic resonance imagingOsteoarthritis, KneeWalking speed

Identifiers

PMID42238190
PMCPMC13228667

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