Evidence map›Paper›PMID 42237938›Full record

ArticleZoological research2026

Integrated spatial transcriptomic and metabolic profiling identifies molecular networks associated with cognitive performance in the porcine prefrontal cortex.

Sheng-Di Cui, Dong Chen, Zhen-Jian Zhao, Qi Shen, Yang Yu, Jun-Ge Wang, Zi-Yang Chen, Shi-Xin Yu, Jia-Miao Chen, Ping-Xian Wu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Zoological research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sheng-Di CuiState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Dong ChenState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Zhen-Jian ZhaoState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Qi ShenState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Yang YuState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Jun-Ge WangState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Zi-Yang ChenState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Shi-Xin YuState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Jia-Miao ChenState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Ping-Xian WuChongqing Academy of Animal Sciences, Chongqing 402460, China.
Zong-Yi GuoChongqing Academy of Animal Sciences, Chongqing 402460, China.
Jin-Yong WangChongqing Academy of Animal Sciences, Chongqing 402460, China.
Xue-Wei LiState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.
Guo-Qing TangState Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pigs possess advanced cognitive capabilities and provide a valuable large-animal model for studying human cognition and neurological disorders. To elucidate the molecular architecture underlying cognitive function, spatial transcriptomics and metabolomics were integrated to generate a high-resolution, multidimensional map of the porcine prefrontal cortex. This framework enabled precise localization of cognition-associated molecular programs within structurally complex neural tissue. Focusing on cortical layers III-V, the spatial distribution of transcripts and metabolites was systematically resolved, identifying

Indexed as

CognitionMetabolomePrefrontal CortexTranscriptomeAnimalsGene Expression RegulationMetabolomicsMultiomicsSpatial TranscriptomicsSwineCognitive abilityPigsSpatial metabolomicsSpatial transcriptomics

Identifiers

PMID42237938
PMCPMC13647064

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.