Evidence map›Paper›PMID 42237694›Full record

Trial reportPhysiological reports2026

Impact of inorganic nitrate on renal sodium excretion during saline loading in healthy adults; secondary endpoints from a randomized crossover trial.

A M Østergaard, J B Rosenbæk, J A Ejlersen, F H Mose, J N Bech, M H Vrist

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

A M ØstergaardUniversity Clinic in Nephrology and Hypertension, Gødstrup Hospital, Herning, Denmark.ORCID https://orcid.org/0000-0001-8812-6852
J B RosenbækUniversity Clinic in Nephrology and Hypertension, Gødstrup Hospital, Herning, Denmark.
J A EjlersenDepartment of Nuclear Medicine, Gødstrup Hospital, Herning, Denmark.
F H MoseUniversity Clinic in Nephrology and Hypertension, Gødstrup Hospital, Herning, Denmark.
J N BechUniversity Clinic in Nephrology and Hypertension, Gødstrup Hospital, Herning, Denmark.
M H VristUniversity Clinic in Nephrology and Hypertension, Gødstrup Hospital, Herning, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inorganic nitrate may lower blood pressure (BP) and enhance natriuresis through nitric oxide (NO) mediated mechanisms. Studies have found inconsistent effects of NO on sodium excretion. Nitric oxide synthase (NOS) inhibition suggests increased NO promotes natriuresis, whereas inorganic nitrate studies remain inconclusive. We conducted a randomized, double-blind, placebo-controlled crossover trial in 18 healthy adults, with 4 days of potassium nitrate (KNO

Indexed as

KidneyNatriuresisNitratesPotassium CompoundsSaline SolutionSodiumAdultBlood PressureCross-Over StudiesCyclic GMPDouble-Blind MethodFemaleHumansMaleNitric OxideYoung AdultCyclic GMPNitratesNitric OxidePotassium Compoundspotassium nitrateSaline SolutionSodiumarginine vasopressinhemodynamicinorganic nitratenitric oxiderenal sodium excretionsaline loading

Identifiers

PMID42237694
PMCPMC13581089

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.