ArticleAnnals of medicine2026
Impact of area socioeconomic deprivation on major adverse renal events in patients with acute kidney injury: a retrospective cohort study of a single-center national patient population.
Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundTo investigate the impact of area socioeconomic deprivation on the risk of major adverse kidney events (MAKEs) within 90 days post-discharge among patients with acute kidney injury (AKI).
methodsThis retrospective cohort study included patients with AKI between January 1, 2014, and December 31, 2023. Area socioeconomic deprivation index was calculated using principal component analysis based on district-level economic and healthcare resource data from patients' registered residential areas. Patients were stratified into four deprivation quartiles (Q1-Q4) and analyzed with multivariable Cox proportional hazards regression models to assess the association between deprivation index and MAKE risk.
resultsAmong 5,934 AKI patients, 1,107 (18.7%) experienced MAKEs within 90-day follow-up. Multivariable Cox regression analysis revealed that patients in the highest deprivation quartile (Q4) had a significantly greater risk of MAKEs than those in the lowest deprivation quartile (Q1) (hazard ratio [HR] 1.48, 95% CI: 1.24-1.77), with a significant dose-response relationship between MAKE risk and (trend
conclusionArea socioeconomic deprivation is a key socioenvironmental determinant of outcome in AKI patients. This finding suggests a significant association of macrolevel social environments on disease outcomes. Therefore, social environment assessments should be integrated into AKI clinical management systems for systematically reducing health inequalities.
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