Evidence map›Paper›PMID 42237568›Full record

ArticleIntegrative cancer therapies

Catalpol Reactivates IL-7R-STAT5 Signaling and Reverses Radiation-Induced T Helper 1 Cells Deficiency to Limit Melanoma Metastasis to Lung.

Shan Zhang, Yue Zhang, Mingyan Ma, Junjie Huang, Rongrui Tang, Wenlian Hao

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Article in Integrative cancer therapies. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Shan ZhangChongqing University (Shapingba District People's Hospital of Chongqing), China.
Yue ZhangTianjin Rehabilitation and Convalescence Center, China.
Mingyan MaSecond Hospital Affiliated to Tianjin Medical University, China.
Junjie HuangChengdu University of TCM, China.
Rongrui TangChongqing University (Shapingba District People's Hospital of Chongqing), China.ORCID 0009-0001-6233-7069
Wenlian HaoTianjin Rehabilitation and Convalescence Center, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRadiation-induced quantitative deficiency of T helper 1 (Th1) cells accelerates lung tumor development. Here, we evaluated IL-7R-STAT5 signaling in Th1 recovery after irradiation and examined how catalpol contributes to Th1 reconstitution by targeting this signaling axis in mice.

methodsThe recovery characteristics of irradiated Th1 cells, compared with other IFN-γ-producing (IFN-γ

resultsTh1 subsets showed delayed recovery in both LRT and SLTBI mice compared with other IFN-γ

conclusionsIL-7R-STAT5 signaling is required for Th1 recovery after irradiation. Catalpol effectively promotes Th1 cell reconstitution and decreases B16 melanoma metastasis to the lung by enhancing IL-7R-STAT5 signaling. These findings provide new strategies for improving radiotherapy and immunotherapy outcomes in cancer.

Indexed as

Iridoid GlucosidesLung NeoplasmsMelanomaMelanoma, ExperimentalReceptors, Interleukin-7STAT5 Transcription FactorTh1 CellsAnimalsCell Line, TumorInterferon-gammaMiceMice, Inbred C57BLSignal TransductioncatalpolInterferon-gammaIridoid GlucosidesReceptors, Interleukin-7STAT5 Transcription FactorcatalpolIL-7RradiotherapySTAT5T helper 1 cells

Identifiers

PMID42237568
PMCPMC13237464

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