Evidence map›Paper›PMID 42237524›Full record

ArticleJournal of diabetes research2026

Metformin and Placental Ferroptosis in Gestational Diabetes: A Mechanistic Study.

Qiannan Lin, Xinyu Qin, Meihong Shen, Dandan Xia, Xiaorong Cao, Guangtong She, Huiyan Wang, Wenbo Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qiannan LinDepartment of Obstetrics and Gynecology, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu, China, njmu.edu.cn.ORCID https://orcid.org/0009-0007-6929-9521
Xinyu QinDepartment of Obstetrics and Gynecology, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu, China, njmu.edu.cn.ORCID https://orcid.org/0009-0000-5172-7400
Meihong ShenDepartment of Obstetrics and Gynecology, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu, China, njmu.edu.cn.ORCID https://orcid.org/0009-0006-5411-8858
Dandan XiaDepartment of Obstetrics and Gynecology, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu, China, njmu.edu.cn.ORCID https://orcid.org/0009-0006-0371-8394
Xiaorong CaoDepartment of Obstetrics, Taizhou Jiangyan Hospital of TCM, Nanjing University of Chinese Medicine, Taizhou, Jiangsu, China, njucm.edu.cn.ORCID https://orcid.org/0009-0002-6051-1606
Guangtong SheDepartment of Obstetrics and Gynecology, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu, China, njmu.edu.cn.ORCID https://orcid.org/0009-0008-0321-6719
Huiyan WangDepartment of Obstetrics and Gynecology, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu, China, njmu.edu.cn.ORCID https://orcid.org/0009-0000-1012-6924
Wenbo ZhouMedical Research Center, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu, China, njmu.edu.cn.ORCID https://orcid.org/0000-0001-7254-3731

Funding

Changzhou Municipal Science and Technology Bureau CJ20220117High-Level Leading Talents Project of Changzhou Health Commission 2022CZLJ023
6 · The paper itself

Abstract

Gestational diabetes mellitus (GDM) is a major contributor to adverse pregnancy outcomes. Although the involvement of ferroptosis in GDM pathogenesis has been recognized, the precise mechanisms remain incompletely understood. This study is aimed at investigating the potential regulatory effects of metformin (Met) on ferroptosis in GDM. Patients with GDM were stratified into four groups: diet-controlled (Group 1), nonmedicated (Group 2), Met-treated (Group Met), insulin-treated (Group Ins), alongside healthy controls (Group N). Placental trophoblasts and HTR-8/SVneo cells were subjected to analysis using transmission electron microscopy (ultrastructure), Prussian blue staining (iron detection), CCK-8 assay (proliferation), DCFH-DA probe (reactive oxygen species [ROS]), and biochemical assays (Fe

Indexed as

Diabetes, GestationalFerroptosisHypoglycemic AgentsMetforminPlacentaTrophoblastsAdultCell LineFemaleHumansOxidative StressPregnancyReactive Oxygen SpeciesHypoglycemic AgentsMetforminReactive Oxygen Speciesferroptosisgestational diabetes mellitusmetformintrophoblasts

Identifiers

PMID42237524
PMCPMC13581051

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.