ArticleJournal of breast cancer2026
Prognostic Implications of Calcification and Surgery Type by Estrogen Receptor and HER2 Status in Ductal Carcinoma
Article in Journal of breast cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeDuctal carcinoma
methodsA retrospective analysis was conducted in 365 patients who underwent surgery for DCIS at The Catholic University of Korea, Seoul St. Mary's Hospital between 1997 and 2020. Ipsilateral breast tumor recurrence (IBTR) and contralateral breast tumor recurrence (CBTR) were evaluated as the primary and secondary endpoints, respectively. Multivariable Cox models were implemented, incorporating radiotherapy, endocrine therapy, and margin status. 1:1 propensity score matching (PSM) was performed to adjust for selection bias between breast-conserving surgery and mastectomy.
resultsER-negative and HER2-positive DCIS were associated with older age, more frequent calcification, and higher nuclear grade (all
conclusionCalcification and surgical modality demonstrated divergent prognostic implications for IBTR and CBTR according to molecular subtype. Although calcification is traditionally considered a high-risk feature prevalent in aggressive subtypes, its presence was associated with favorable contralateral events in ER+ DCIS. These findings emphasize the importance of integrating molecular markers with clinical features to support more personalized approaches to DCIS management.
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