Evidence map›Paper›PMID 42237407›Full record

ArticleTrials2026

Behavioral telehealth in low-resource primary care settings for anxiety and depression in youth: protocol for a randomized effectiveness-implementation study.

Francesca Rodriguez, Frances L Lynch, Araceli Gonzalez, Michelle Rozenman, John Dickerson, Maureen O'Keeffe-Rosetti, Judy Donald, Brigit Hatch, Gordon Barker, Michelle Henninger and 3 more

Registry-linked trialAbstract readClinical Trial Protocol
In one paragraph

Article in Trials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06273982 (Behavioral Telehealth in Low-resource Primary Care Settings for Anxiety and Depression in Youth), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06273982 naenrolling by invitationnot on this map

Behavioral Telehealth in Low-resource Primary Care Settings for Anxiety and Depression in Youth: A Randomized Effectiveness-implementation Study

TypeinterventionalSponsorSan Diego State UniversityRan2024 to 2028Enrolled220ConditionsDepression, AnxietyArmsSTEP-UP (transdiagnostic behavioral therapy for pediatric anxiety and depression), ARC (assisted referral to community care)
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Francesca RodriguezSan Diego State University, San Diego, USA. ferodriguez@sdsu.ed.ORCID http://orcid.org/0009-0008-6971-2213
Frances L LynchCenter for Health Research, Kaiser Permanente Northwest, Portland, USA.
Araceli GonzalezCalifornia State University, Long Beach, Long Beach, USA.
Michelle RozenmanUniversity of Denver, Denver, USA.
John DickersonCenter for Health Research, Kaiser Permanente Northwest, Portland, USA.
Maureen O'Keeffe-RosettiCenter for Health Research, Kaiser Permanente Northwest, Portland, USA.
Judy DonaldCenter for Health Research, Kaiser Permanente Northwest, Portland, USA.
Brigit HatchOCHIN inc., Portland, USA.
Gordon BarkerOCHIN inc., Portland, USA.
Michelle HenningerCenter for Health Research, Kaiser Permanente Northwest, Portland, USA.
Meagan ShawCenter for Health Research, Kaiser Permanente Northwest, Portland, USA.
Katherine A VaughnCenter for Health Research, Kaiser Permanente Northwest, Portland, USA.
V Robin WeersingSan Diego State University, San Diego, USA.

Funding

Behavioral telehealth in low-resource primary care settings for anxiety and depression in youth: A randomized effectiveness-implementation studyR01MH131698 · NIMH · SAN DIEGO STATE UNIVERSITY · PI FRANCES L LYNCH, V Robin Weersing · 2023 to 2026
$4.1M
Video-visit behavior therapy for anxiety and depression in youth: A randomized effectiveness-implementation study in low-resource primary care settings.R56MH125159 · NIMH · SAN DIEGO STATE UNIVERSITY · PI LYNCH, FRANCES L, WEERSING, V ROBIN · 2020 to 2021
$789k
National Institute of Mental Health (NIMH) R01MH131698NIMH NIH HHS R01 MH131698NIMH NIH HHS R56 MH125159
6 · The paper itself

Abstract

backgroundAnxiety and mood disorders in youth are prevalent and impairing, with high current and lifetime comorbidity. Untreated, these disorders lead to sustained functional impairment and increased risk for recurrent disorder and suicide. In addition, there are notable disparities in care, with both families experiencing increased social risk and youth of color significantly less likely to receive mental health services. In previous research, a primary-care-based transdiagnostic brief behavioral therapy (BBT) was developed and found to be effective for a broad population of youths with anxiety and depression. To increase dissemination potential to settings that serve low-resource families (e.g., community health centers [CHCs]), the intervention, now called "STEP-UP," has been expanded to support a digital health framework and delivery in Spanish. We describe the protocol for a hybrid type 1 randomized-effectiveness trial to test the effects of STEP-UP in a community sample of youths with anxiety and/or depression.

methodYouths (age = 8-16, N = 220) will be randomized to (a) STEP-UP or (b) assisted referral to treatment as usual (TAU+). Clinical effectiveness will be assessed by masked independent evaluators at posttreatment (week 16) and at follow-up (week 32). Implementation data will be pulled from the following: (a) Surveys of health system leaders, (b) surveys of and interviews with STEP-UP clinicians, and (c) electronic health record (EHR) and health system administrative data. Specific aims include testing the clinical effectiveness of STEP-UP and engagement of the intervention mechanism (Aim 1), probing cost-effectiveness (Aim 2), testing social determinants of health (SDOH) predictors and moderators to evaluate robustness of effects (Aim 3), and identifying target mechanisms for future implementation trials using the Consolidated Framework for Implementation Research (CFIR, Aim 4). DISCUSSION: Results of the randomized trial may help move effective treatments for youth anxiety and depression problems into widespread community practice.

trial registrationNCT06273982. Registered on February 15, 2024.

Indexed as

Adolescent BehaviorAnxietyChild BehaviorDepressionPrimary Health CareAdolescentChildCost-Benefit AnalysisHealth ResourcesHumansMental Health TeletherapyRandomized Controlled Trials as TopicTelemedicineTime FactorsTreatment OutcomeAnxietyBehavioral healthClinical trialDepressionPrimary carePsychosocial interventionsTransdiagnosticYouth

Identifiers

PMID42237407
PMCPMC13449585

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.