ArticleCardio-oncology (London, England)2026
Associations between extreme temperatures and hospitalizations among Chinese cancer patients with atrial fibrillation: a case-crossover study.
Article in Cardio-oncology (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundTemperature extremes are established triggers of cardiovascular events in the general population, while cancer patients face elevated atrial fibrillation (AF) risk due to disease- and treatment-related factors. However, whether cancer confers additional vulnerability to temperature-related AF events remains unclear. This study aimed to examine the association between extreme temperatures and AF hospitalizations in cancer patients compared with non-cancer controls.
methodsData were derived from the real-world study of the Chinese AF registry (2014-2023), comprising 1,665,014 AF hospitalizations. This study is an exploratory, cancer-focused secondary analysis of the RWS-CAF registry. Overall associations between ambient temperature and AF hospitalization in the full registry have been reported separately. We used a time-stratified case-crossover design with distributed lag nonlinear models to assess temperature-AF associations. Cancer patients (n = 243482) were compared with demographically matched non-cancer controls, and unmatched analyses were performed in the full cohort. Subgroup analyses examined effect modification by age, sex, and geographic region.
resultsExtreme cold (1st percentile, - 5.6 °C) was associated with higher AF hospitalization risk in cancer patients (RR 1.80, 95% CI 1.60-2.03) compared with matched non-cancer controls (RR 1.27, 95% CI 1.21-1.34; P
conclusionsPatients with cancer appeared more vulnerable to cold-related AF hospitalization than those without cancer, with stronger associations observed in men and in northern regions. These findings support the possibility that cancer modifies the temperature-AF relationship and warrant confirmation in studies with prespecified analyses and more detailed oncologic characterization.
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