Evidence map›Paper›PMID 42237290›Full record

ArticleBMC psychiatry2026

Bidirectional longitudinal associations between social activity and depressive symptoms among Chinese older adults with multimorbidity: the moderating role of subjective life expectancy.

Xinru Li, Lei Shi, Shujuan Xiao, Benli Xue, Lingli Yang, Xiao Zheng, Xinyi Zhang, Mengjie Zhang, Yanming Liao, Chichen Zhang

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Article in BMC psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

10 authors.

Xinru LiSchool of Public Health, Southern Medical University, Guangzhou, China.
Lei ShiKey Laboratory of Philosophy and Social Sciences of Colleges and Universities in Guangdong Province for Collaborative Innovation of Health Management Policy and Precision Health Service, Guangzhou, China.
Shujuan XiaoKey Laboratory of Philosophy and Social Sciences of Colleges and Universities in Guangdong Province for Collaborative Innovation of Health Management Policy and Precision Health Service, Guangzhou, China.
Benli XueSchool of Public Health, Southern Medical University, Guangzhou, China.
Lingli YangSchool of Health Management, Southern Medical University, No.1023 Shatai South Road, Baiyun District, Guangzhou, Guangdong, 510515, China.
Xiao ZhengSchool of Health Management, Southern Medical University, No.1023 Shatai South Road, Baiyun District, Guangzhou, Guangdong, 510515, China.
Xinyi ZhangSchool of Public Health, Southern Medical University, Guangzhou, China.
Mengjie ZhangSchool of Health Management, Southern Medical University, No.1023 Shatai South Road, Baiyun District, Guangzhou, Guangdong, 510515, China.
Yanming LiaoSchool of Public Health, Southern Medical University, Guangzhou, China.
Chichen ZhangSchool of Public Health, Southern Medical University, Guangzhou, China. zhangchichen@sina.com.

Funding

National Natural Science Foundation of China 72274091
6 · The paper itself

Abstract

backgroundSocial activity in older adults is often correlated with their depressive symptoms, and this correlation is stronger in older adults with multimorbidity than in those without. However, few studies have analyzed this longitudinal association over time. This study aimed to examine the bidirectional longitudinal associations between social activity and depressive symptoms in older adults with multimorbidity. Additionally, we examined subjective life expectancy's (SLE) moderating association in this bidirectional longitudinal association.

methodsData were obtained from Waves 3 and 4 survey of 1435 older adults with multimorbidity (≥ 60 years) enrolled in the China Health and Retirement Longitudinal Study. We used cross-lagged panel models and grouped regression models to analyze the bidirectional longitudinal association between social activity and depressive symptoms, as well as the moderating association of subjective life expectancy, among Chinese older adults with multimorbidity.

resultsT1 social activity was significantly negatively associated with T2 depressive symptoms (β=-0.054, P < 0.050), and T1 depressive symptoms were significantly negatively associated with T2 social activity (β=-0.112, P < 0.010). SLE significantly moderated the association between T1 social activity and T2 depressive symptoms. Further, among participants with high SLE, the absolute value of the regression coefficient for the negative association of T1 social activity with T2 depressive symptoms (β=-0.134, P < 0.010) was larger than that for the association of T1 depressive symptoms with T2 social activity (β=-0.114, P < 0.050), indicating a more pronounced negative association for the former. All reported standardized coefficients were relatively modest; nevertheless, these statistically significant longitudinal associations are clinically and public health-relevant in this high-risk cohort of older adults with multimorbidity, who are disproportionately vulnerable to depressive symptom progression and social disengagement.

conclusionReciprocal longitudinal associations between social activity and depressive symptoms were observed among Chinese older adults with multimorbidity, with the negative longitudinal association from baseline depressive symptoms to subsequent social activity being larger in magnitude than the reverse association. Additionally, subjective life expectancy (SLE) showed a significant moderating effect on the association from baseline social activity to subsequent depressive symptoms.

Indexed as

DepressionLife ExpectancyMultimorbidityAgedAged, 80 and overChinaEast Asian PeopleFemaleHumansLongitudinal StudiesMaleMiddle AgedDepressive symptomsHealth managementMultimorbiditySocial activitySubjective life expectancy

Identifiers

PMID42237290
PMCPMC13463951

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