Trial reportBMC oral health2026
Effect of an oral care bundle on salivary pH, dry mouth and ventilator-associated pneumonia in intubated patients: a randomized controlled trial.
Trial report in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06258603 (The Effect of Oral Care Bundle Application on Salivary pH), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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The Effect of Oral Care Bundle Application on Salivary pH (Power of Hydrogen), Dry Mouth and Ventilator-associated Pneumonia in Intubated Patients
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMore serious and costly problems can be prevented with systematic and holistic oral care, which seems to be less important among nursing practices.
objectivesTo determine the effectiveness of oral care bundle on oral health, saliva volume, saliva pH and VAP in intubated patients.
methodsThis randomized controlled trial data was collected between January and December 2021 in the Anesthesiology and Reanimation ICUs at a university hospital. Patients were randomly assigned to intervention and control groups. While routine oral care was applied to the control group (abeslang wrapped in gauze), the intervention group was given care with the oral care bundle created by the researchers (brushing teeth, applying ice water, moisturizing). The primary outcome was the oral health score (BOE), and the primary endpoint was defined as the BOE score at Day 5. Secondary outcomes included saliva volume, salivary pH, ventilator-associated pneumonia. Repeated measures were analyzed using two-way repeated measures ANOVA for normally distributed variables and the Brunner-Langer model for non-normally distributed data.
resultsA total of 35 patients were analyzed (intervention: n = 17; control: n = 18). A significant group × time interaction was observed for the BOE score (p < 0.001), indicating an improvement in oral health over time in the intervention group compared with the control group. Similarly, a significant group × time interaction was found for saliva volume (p < 0.001). For salivary pH, a statistically significant interaction was also observed (p < 0.001); however, these findings should be interpreted with caution due to the subjective nature of the measurement method. Although the incidence of VAP and bacterial growth tended to be lower in the intervention group, the differences were not statistically significant between groups.
conclusionsThe intervention improved oral health outcomes in intubated ICU patients, particularly in terms of BOE score and saliva volume. However, findings related to salivary pH and VAP should be interpreted with caution due to methodological limitations and limited statistical power. Further studies with larger samples and more objective measurement methods are needed.
trial registrationThe study has been retrospectively registered on clinicaltrials.gov (Clinical Trials ID: NCT06258603/05.02.2024).
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