Evidence map›Paper›PMID 42237249›Full record

ArticleBMC medical research methodology2026

The survival double descent: generalization dynamics of deep neural networks in time-to-event analysis.

Steven N Hart, Ann L Oberg

Abstract read
In one paragraph

Article in BMC medical research methodology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

2 authors.

Steven N HartDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA. hart.steven@mayo.edu.ORCID https://orcid.org/0000-0001-7714-2734
Ann L ObergDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, 55905, USA.ORCID https://orcid.org/0000-0003-2539-9807

Funding

Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancerP50CA136393 · NCI · MAYO CLINIC ROCHESTER · PI ELLEN L. GOODE · 2009 to 2026
$37.0M
Mayo Clinic SPORE in Ovarian Cancer Grant P50-CA136393NCI NIH HHS P50 CA136393
6 · The paper itself

Abstract

Recent work on double descent has challenged classical bias-variance tradeoffs, showing that test error can decrease, increase sharply near the interpolation threshold, and then decrease again as model capacity grows. This phenomenon has been documented in regression and classification, but its relevance to survival analysis remains unclear. Survival data are subject to censoring, which obscures true event times, and widely used models such as the Cox proportional hazards model are optimized via partial likelihoods that emphasize ranking rather than calibrated risk estimation. It is therefore unknown whether double descent occurs in this setting, how censoring influences its manifestation, or how it interacts with standard performance metrics.We investigate these questions using synthetic survival data generated from Weibull hazards with controlled censoring, allowing systematic variation of model capacity from under to over parameterized regimes.While we verified double descent occurs in survival models, calibration plateaus and decouples from discrimination, even under strong [Formula: see text] regularization. This decoupling arises because the Cox partial likelihood optimizes rankings rather than magnitudes, producing extreme risk scores that break the Breslow estimator used to estimate survival probabilities. Validation on two real-world clinical datasets, the METABRIC breast cancer cohort and the SUPPORT study of seriously ill hospitalized adults, confirms the calibration-discrimination decoupling: IBS saturates at a constant value as network width grows while concordance varies, reproducing the primary synthetic finding across distinct clinical domains and sample sizes. These results highlight limitations of discrimination-based model selection in survival analysis and underscore the need for calibration-aware evaluation in high-capacity prognostic models.

Indexed as

Neural Networks, ComputerAlgorithmsFemaleHumansLikelihood FunctionsProportional Hazards ModelsSurvival AnalysisCox proportional hazardsDouble descentModel calibrationNeural networksSurvival analysis

Identifiers

PMID42237249
PMCPMC13465384

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.