Evidence map›Paper›PMID 42237205›Full record

ReviewJournal of cellular and molecular medicine2026

GGAs: Regulation of Multiple Sorting Pathways and Potential Association With Human Diseases.

Qinqin Wang, Juan Mei, Shuyue Li, Guoan Zhang, Jian Qiu, Xuezhi Li

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of cellular and molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qinqin WangShandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions of Mental Disorders, Institute of Mental Health, Jining Medical University, Jining, China.ORCID 0000-0003-2741-1566
Juan MeiShandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions of Mental Disorders, Institute of Mental Health, Jining Medical University, Jining, China.
Shuyue LiJining Key Laboratory of Forensic Multimodal Precision Identification, School of Forensic Medicine, Jining Medical University, Jining, China.ORCID 0009-0008-4224-5766
Guoan ZhangJining Key Laboratory of Forensic Multimodal Precision Identification, School of Forensic Medicine, Jining Medical University, Jining, China.ORCID 0000-0002-9489-6033
Jian QiuDepartment of Neurology, Affiliated Hospital of Jining Medical University, Jining, China.
Xuezhi LiShandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions of Mental Disorders, Institute of Mental Health, Jining Medical University, Jining, China.ORCID 0000-0003-1030-9688

Funding

National Natural Science Foundation of China 82301629Natural Science Foundation of Shandong Province ZR2021QC039Natural Science Foundation of Shandong Province ZR2022MH244
6 · The paper itself

Abstract

Golgi-localized gamma-ear-containing Arf-binding proteins (GGAs) are a family of monomeric clathrin adaptors that function in intracellular vesicle trafficking. The three GGA family members-GGA1, GGA2 and GGA3-were first identified as sorting adaptors almost simultaneously by independent research groups in 2000. It is now well established that GGAs exert broad functions in intracellular sorting pathways. Moreover, GGAs have been shown to participate in diverse cellular processes including cell survival, migration and invasion, and are proposed to be potentially associated with multiple human disorders, such as Alzheimer's disease, cancers and type 2 diabetes mellitus. In this review, we briefly summarize the current knowledge regarding the roles of GGAs in intracellular vesicle trafficking, discuss the regulatory mechanisms underlying their functions, and speculate on their potential implications in human diseases. These findings may help us understand how GGAs participate in the pathogenesis of human diseases and, in the future, how to intervention the diseases via GGA-targeted strategies.

Indexed as

Adaptor Proteins, Vesicular TransportAlzheimer DiseaseDiabetes Mellitus, Type 2NeoplasmsAnimalsGolgi ApparatusHumansProtein TransportSignal TransductionAdaptor Proteins, Vesicular TransportGGA adaptor proteinsAlzheimer's diseasecancerGolgi‐localized gamma‐ear‐containing Arf‐binding proteinsorting adaptortype 2 diabetes mellitus

Identifiers

PMID42237205
PMCPMC13581114

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.