Evidence map›Paper›PMID 42237119›Full record

ArticleBMC pulmonary medicine2026

Blood eosinophil count and clinical characteristics according to etiology in chronic obstructive pulmonary disease.

Jeong Hyeon Seong, Hee-Young Yoon, Ye Jin Lee, Hyonsoo Joo, Joo Hun Park, Seong Yong Lim, Sang Yeub Lee, Hyoung Kyu Yoon, Kwang Ha Yoo, Chin Kook Rhee

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Article in BMC pulmonary medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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10 authors.

Jeong Hyeon SeongDepartment of Internal Medicine, Division of Pulmonary and Critical Care Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
Hee-Young YoonDepartment of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Soonchunhyang University Seoul Hospital, Seoul, Republic of Korea.
Ye Jin LeeDepartment of Internal Medicine, Division of Pulmonology and Critical Care Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Hyonsoo JooDepartment of Internal Medicine, Division of Pulmonary and Critical Care Medicine, College of Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
Joo Hun ParkDepartment of Pulmonary and Critical Care Medicine, Ajou University School of Medicine, Suwon, Republic of Korea.
Seong Yong LimDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Sang Yeub LeeDepartment of Internal Medicine, Division of Pulmonology, Allergy and Critical Care Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
Hyoung Kyu YoonDepartment of Internal Medicine, Division of Pulmonary and Critical Care Medicine, College of Medicine, Yeouido St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
Kwang Ha YooDepartment of Internal Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05030, Republic of Korea.
Chin Kook RheeDepartment of Internal Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, 120 Neungdong-ro, Gwangjin-gu, Seoul, 05030, Republic of Korea. chinkook77@gmail.com.

Funding

Korea National Institute of Health 2016ER670100, 2016ER670101, 2016ER670102, 2018ER67100, 2018ER67101, 2018ER67102, 2021ER120500, 2021ER120501, 2021ER120502, 2024ER120100, and 2024ER120101
6 · The paper itself

Abstract

backgroundChronic obstructive pulmonary disease (COPD) is a heterogeneous condition with multiple etiologies. We evaluated whether clinical characteristics differ according to COPD etiology.

methodsPatients with infection as the sole etiology were classified as the infection-related group (COPD-I, Group I), whereas those with any smoking-related etiology were assigned to the smoking-related group (COPD-C, Group C).

resultsOf 873 patients included, 41 were classified as Group I and 832 as Group C. A significantly higher proportion of patients in Group I had a blood eosinophil count < 100 cells/µL compared to Group C (44.4% vs. 27.8%; p = 0.031). The inhaled corticosteroid (ICS) prescription rate was lower in Group I compared to Group C (25.7% vs. 41.5%; p = 0.063). Multivariable logistic regression confirmed that Group I was independently associated with a lower likelihood of ICS use (p = 0.018). In addition, Group I exhibited a significantly higher residual volume to total lung capacity ratio (48.88% vs. 43.28%; p = 0.030), indicating greater air trapping and small airway involvement.

conclusionsThese findings support the notion that infection-related COPD (COPD-I) represents a clinically distinct phenotype.

Indexed as

EosinophilsPulmonary Disease, Chronic ObstructiveRespiratory Tract InfectionsSmokingAdministration, InhalationAdrenal Cortex HormonesAgedFemaleHumansLeukocyte CountLogistic ModelsMaleMiddle AgedMultivariate AnalysisRetrospective StudiesTotal Lung CapacityAdrenal Cortex HormonesChronic obstructive pulmonary diseaseEosinophilEtiologyInhaled corticosteroidsSmall airway disease

Identifiers

PMID42237119
PMCPMC13450063

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.