Evidence map›Paper›PMID 42237060›Full record

ArticleThe Journal of pathology2026

Dopamine inhibits retinal pathological neovascularization in the oxygen-induced retinopathy mouse model.

Qi Wang, Jiajia Shi, Shuai Ouyang, Tingting Zhang, Haoran Yang, Jiadi Zhu, Luyao Wang, Yuan Lv, Sisi Dong, Ruyi Chen and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Qi Wang *State Key Laboratory of Eye Health, Oujiang Laboratory, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Zhejiang, PR China.
Jiajia Shi *State Key Laboratory of Eye Health, Oujiang Laboratory, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Zhejiang, PR China.
Shuai Ouyang *State Key Laboratory of Eye Health, Oujiang Laboratory, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Zhejiang, PR China.ORCID https://orcid.org/0000-0002-6199-3742
Tingting ZhangState Key Laboratory of Eye Health, Oujiang Laboratory, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Zhejiang, PR China.
Haoran YangState Key Laboratory of Eye Health, Oujiang Laboratory, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Zhejiang, PR China.
Jiadi ZhuState Key Laboratory of Eye Health, Oujiang Laboratory, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Zhejiang, PR China.
Luyao WangState Key Laboratory of Eye Health, Oujiang Laboratory, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Zhejiang, PR China.
Yuan LvState Key Laboratory of Eye Health, Oujiang Laboratory, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Zhejiang, PR China.
Sisi DongState Key Laboratory of Eye Health, Oujiang Laboratory, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Zhejiang, PR China.
Ruyi ChenState Key Laboratory of Eye Health, Oujiang Laboratory, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Zhejiang, PR China.
Xuemei LingState Key Laboratory of Eye Health, Oujiang Laboratory, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Zhejiang, PR China.
Shiming JiaoState Key Laboratory of Eye Health, Oujiang Laboratory, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Zhejiang, PR China.
Mengmeng DongState Key Laboratory of Eye Health, Oujiang Laboratory, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Zhejiang, PR China.
Wenjun YanState Key Laboratory of Eye Health, Oujiang Laboratory, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Zhejiang, PR China.
Jinglei YangState Key Laboratory of Eye Health, Oujiang Laboratory, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Zhejiang, PR China.
Biao YanDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.
Jiangfan ChenState Key Laboratory of Eye Health, Oujiang Laboratory, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Zhejiang, PR China.
Jia QuState Key Laboratory of Eye Health, Oujiang Laboratory, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Zhejiang, PR China.
Fei ZhaoState Key Laboratory of Eye Health, Oujiang Laboratory, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Zhejiang, PR China.
Xiangtian ZhouState Key Laboratory of Eye Health, Oujiang Laboratory, National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Zhejiang, PR China.ORCID https://orcid.org/0000-0003-0350-1356

Funding

the National Natural Science Foundation of China 82025009the National Natural Science Foundation of China 82171097the National Natural Science Foundation of China 82388101the National Natural Science Foundation of China 82422019the National Natural Science Foundation of China U20A20364the National Natural Science Foundation of China U23A20438
6 · The paper itself

Abstract

Pathological neovascularization is the leading cause of childhood blindness in retinopathy of prematurity (ROP). Anti-vascular endothelial growth factor agents are commonly used to treat this condition, yet their variable efficacy and off-target effects demand alternative strategies. Here, we investigated the relationship between retinal dopamine (DA) dynamics and pathological angiogenesis in the oxygen-induced retinopathy (OIR) mouse model mimicking ROP pathogenesis. We determined the individual effects of apomorphine (APO), a non-selective DA receptor agonist, and selective agonists or antagonists of dopamine D1 receptor (Drd1) and dopamine D2 receptor (Drd2), on pathological neovascularization. Integrating single-cell RNA sequencing with Müller cell-specific Drd2 knockout OIR mice, we identified that Drd2-mediated signaling in Müller cells orchestrates hypoxia-inducible factor alpha and vascular endothelial growth factor A biosynthesis in Müller cells during the hypoxic-ischemic phase of OIR. Collectively, OIR-induced dopaminergic deficiency and impaired Drd2 activity in Müller cells synergistically exacerbate pathological angiogenesis. © 2026 The Pathological Society of Great Britain and Ireland.

Indexed as

DopamineRetinal NeovascularizationRetinopathy of PrematurityAnimalsApomorphineDisease Models, AnimalDopamine AgonistsEpendymoglial CellsHypoxia-Inducible Factor 1, alpha SubunitMiceMice, Inbred C57BLMice, KnockoutOxygenReceptors, Dopamine D1Receptors, Dopamine D2Signal TransductionApomorphineDopamineDopamine AgonistsDrd1 protein, mouseDRD2 protein, mouseHypoxia-Inducible Factor 1, alpha SubunitOxygenReceptors, Dopamine D1Receptors, Dopamine D2Vascular Endothelial Growth Factor Adopaminedopamine D2 receptorMüller cellsoxygen‐induced retinopathyretinopathy of prematurity

Identifiers

PMID42237060
PMCPMC13432403

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.