ArticleNature neuroscience2026
The representational geometry of emotional states in basolateral amygdala.
Article in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Lasting aversive consequences of a single dose of 4-hydroxytamoxifen.bioRxiv : the preprint server for biology · 2026Article
- Amygdalostriatal transition zone neurons encode sustained cue responses to guide defensive behaviors.Neuron · 2026Article
- Representations of the intrinsic value of information in mouse orbitofrontal cortex.Nature neuroscience · 2026Article
- The representational geometry of emotional states in basolateral amygdala.Nature neuroscience · 2026Article
- Article
- Decodanda: a Python toolbox for best-practice decoding and geometric analysis of neural representations.bioRxiv : the preprint server for biology · 2026Article
- A mathematical theory for understanding when abstract representations emerge in neural networks.ArXiv · 2026Article
- Anxiety and Beyond: Diversity in Ventral Hippocampus Circuits and Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Heterogeneous plasticity of amygdala interneurons in associative learning and extinction.Nature communications · 2025Article
- Article
- Rarely categorical, always high-dimensional: how the neural code changes along the cortical hierarchy.bioRxiv : the preprint server for biology · 2025Article
- Modular representations emerge in neural networks trained to perform context-dependent tasks.bioRxiv : the preprint server for biology · 2024Article
- Review
- Tuned geometries of hippocampal representations meet the computational demands of social memory.Neuron · 2024Article
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8 authors.
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Abstract
Neurons in basolateral amygdala (BLA) encode positive and negative valence. However, many additional variables must be represented to describe all aspects of emotional states. To investigate how BLA encodes these states, we presented mice with conditioned stimuli that elicited two behavioral responses: tremble and ingress into a burrow, reflecting fear and flight to safety, respectively. BLA inactivation eliminated several aspects of differential responses to aversive versus neutral stimuli without eliminating tremble and ingress themselves, consistent with BLA's encoding valence not motor commands. However, individual neurons rarely represented only valence, exhibiting, instead, mixed selectivity for stimulus identity, stimulus valence, tremble and/or ingress. Despite prevalent mixed selectivity, population activity sometimes realized a representational geometry that conferred two computational properties defining specialized readouts: generalization across conditions and no interference between readouts of different variables. These specialized readouts enable output responses to depend on one specific variable and to remain unaffected by the others.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.