ReviewNature reviews. Molecular cell biology2026
Tight junction structure, assembly and (dys)function.
Review in Nature reviews. Molecular cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Biophysics of lumen morphogenesis.Development (Cambridge, England) · 2026Review
- CLDN18 and FGFR2 splicing variants are emerging tumor-associated antigens for cancer therapy.Frontiers in molecular medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tight junctions (TJs) regulate paracellular permeability, cell polarity and cell mechanics of barrier-forming tissues. This Review explores how TJs adapt their structure and function across tissues, with a focus on the claudin-based strand network, its regulation by zonula occludens scaffold proteins and its dysfunction in human diseases. We discuss recent insights into TJ assembly through biomolecular condensation, highlighting how scaffold self-organization integrates adhesion, actin dynamics and polarity cues. We examine TJ maintenance across timescales, from rapid protein turnover to long-term remodelling during development. Finally, we focus on TJ function in lumen formation and review TJ dysfunctions and strategies to target TJ proteins therapeutically. We close by highlighting emerging approaches to tackle open structural, mechanical and functional questions of TJ physiology and pathology.
Indexed as
Identifiers
42236999What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.