Evidence map›Paper›PMID 42236997›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2026

Therapeutic hypothermia and in-hospital mortality in 35-week infants with encephalopathy.

Hany Aly, Hatem Eltaly, Farah A Mohamed, Firas Saker, Ceyda Acun, Mohamed A Mohamed

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Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hany AlyDivision of Neonatology, Cleveland Clinic Women's & Children's Institute, Cleveland, OH, USA. alyh@ccf.org.ORCID http://orcid.org/0000-0001-7395-6394
Hatem EltalyDivision of Neonatology, Cleveland Clinic Women's & Children's Institute, Cleveland, OH, USA.ORCID http://orcid.org/0009-0000-9934-3887
Farah A MohamedDivision of Neonatology, Cleveland Clinic Women's & Children's Institute, Cleveland, OH, USA.
Firas SakerDivision of Neonatology, Cleveland Clinic Women's & Children's Institute, Cleveland, OH, USA.
Ceyda AcunDivision of Neonatology, Cleveland Clinic Women's & Children's Institute, Cleveland, OH, USA.
Mohamed A MohamedDivision of Neonatology, Cleveland Clinic Women's & Children's Institute, Cleveland, OH, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTherapeutic hypothermia (TH) improves outcomes in infants ≥36 weeks with HIE, although safety at 35weeks remains uncertain. We compared TH utilization and associated outcomes in 35- versus 36-week infants with HIE. STUDY

designUsing the 2016-2022 National Inpatient Sample, we identified 35- and 36-week infants with HIE. The primary outcome was in-hospital mortality; secondary outcomes included coagulopathy and other complications. Logistic regression adjusted for covariates; Cochran-Armitage tested trends in TH use.

resultsAmong 1,397,680 infants, HIE occurred in 2354 (0.48%) at 35 weeks and 3972 (0.44%) at 36 weeks; in-hospital mortality was similar (9.98% vs 9.99%). TH was less frequently used at 35 weeks (19.8% vs 22.4%) but increased over time (p < 0.001). 35-week treated infants had higher unadjusted in-hospital mortality (10.3% vs 6.8%) and coagulopathy (28.7% vs 18.4%); adjusted in-hospital mortality did not differ.

conclusionTH use at 35 weeks is increasing that was not associated with differences in in-hospital mortality. Prospective studies are needed to define its role.

Identifiers

PMID42236997

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.