Evidence map›Paper›PMID 42236948›Full record

ArticleNature2026

A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome.

Manpreet Kaur, Dmitrii Y Travin, Max J Berger, Manoj Jangra, Martino Morici, Haaris A Safdari, Dorota Klepacki, Wenliang Wang, Michael Cook, Sommer Chou and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. A new antibiotic scaffold hits a new target.Nature reviews. Microbiology · 2026
    Article
  2. Approaches for Studying Context Specificity of Translation Inhibitor Action.International journal of molecular sciences · 2026
    Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Manpreet Kaur *David Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.ORCID http://orcid.org/0000-0002-2506-0611
Dmitrii Y Travin *Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-0189-0159
Max J Berger *Institute for Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany.ORCID http://orcid.org/0009-0001-7093-9086
Manoj JangraDavid Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.ORCID http://orcid.org/0000-0003-3423-7105
Martino MoriciInstitute for Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany.
Haaris A SafdariInstitute for Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany.ORCID http://orcid.org/0000-0003-3533-090X
Dorota KlepackiDepartment of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL, USA.
Wenliang WangDavid Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.
Michael CookDavid Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.
Sommer ChouDavid Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.ORCID http://orcid.org/0000-0001-7742-7350
Allison K GuitorDavid Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.ORCID http://orcid.org/0000-0002-6290-6233
Kalinka KotevaDavid Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.ORCID http://orcid.org/0000-0002-6446-9567
Min XuDavid Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.ORCID http://orcid.org/0000-0002-6661-5177
Linda EjimDavid Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.
Aline FiebigDavid Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.ORCID http://orcid.org/0009-0009-0786-4331
Yeganeh YousefiDavid Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.
Brian K CoombesDavid Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.ORCID http://orcid.org/0000-0001-9883-1010
Lesley MacneilDavid Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada.
Nora Vázquez-LaslopDepartment of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-2256-693X
Alexander S MankinDepartment of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL, USA. shura@uic.edu.ORCID http://orcid.org/0000-0002-3301-827X
Daniel N WilsonInstitute for Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany. daniel.wilson@uni-hamburg.de.
Gerard D WrightDavid Braley Centre for Antibiotics Discovery, McMaster University, Hamilton, Ontario, Canada. wrightge@mcmaster.ca.ORCID http://orcid.org/0000-0002-9129-7131

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A key challenge in addressing the antibiotic resistance crisis is identifying new antimicrobial compounds

Indexed as

Anti-Bacterial AgentsBiological ProductsDepsipeptidesDrug DiscoveryStreptomycesBinding SitesCryoelectron MicroscopyModels, MolecularProtein BiosynthesisRibosomesRibosome Subunits, Large, BacterialAnti-Bacterial AgentsBiological ProductsDepsipeptides

Identifiers

PMID42236948
PMCPMC13372681

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.