Evidence map›Paper›PMID 42236947›Full record

ArticleNature2026

Spermine is an endogenous iron chelator that inhibits ferroptosis.

Man Li, Xuexin Yu, Shuqin Ouyang, Xiaohong Chen, Huiqi Yu, Yuanji Liu, Ziwen Li, Chunhua Yu, Rui Kang, Christine Gaillet and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Ferroptosis in liver biology and diseases.Hepatology communications · 2026
    Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Man LiState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
Xuexin YuDepartment of Biochemistry, Zhongshan School of Medicine Sun Yat-sen University, Guangzhou, China.
Shuqin OuyangDepartment of Biochemistry, Zhongshan School of Medicine Sun Yat-sen University, Guangzhou, China.
Xiaohong ChenDepartment of Biochemistry, Zhongshan School of Medicine Sun Yat-sen University, Guangzhou, China.
Huiqi YuDepartment of Biochemistry, Zhongshan School of Medicine Sun Yat-sen University, Guangzhou, China.
Yuanji LiuDepartment of Biochemistry, Zhongshan School of Medicine Sun Yat-sen University, Guangzhou, China.
Ziwen LiDepartment of Biochemistry, Zhongshan School of Medicine Sun Yat-sen University, Guangzhou, China.
Chunhua YuDepartment of Surgery, UT Southwestern Medical Center, Dallas, TX, USA.
Rui KangDepartment of Surgery, UT Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0003-2725-1574
Christine GailletInstitut Curie, CNRS, INSERM, PSL Research University, Paris, France.ORCID http://orcid.org/0000-0002-1208-1130
Ludovic ColombeauInstitut Curie, CNRS, INSERM, PSL Research University, Paris, France.ORCID http://orcid.org/0000-0001-5823-2603
Raphaël RodriguezInstitut Curie, CNRS, INSERM, PSL Research University, Paris, France.ORCID http://orcid.org/0000-0001-7668-446X
Libing SongState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China. songlb@sysucc.org.cn.ORCID http://orcid.org/0000-0002-5315-771X
Guido KroemerUniversité Paris Cité, Sorbonne Université, INSERM, Centre de Recherche des Cordeliers, Paris, France. kroemer@orange.fr.ORCID http://orcid.org/0000-0002-9334-4405
Daolin TangDepartment of Surgery, UT Southwestern Medical Center, Dallas, TX, USA. daolin.tang@utsouthwestern.edu.ORCID http://orcid.org/0000-0002-1903-6180
Jun LiState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China. lijun37@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0003-0572-1344

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ferroptosis is an iron-dependent form of cell death driven by lipid peroxidation

Indexed as

FerroptosisIronSpermineAnimalsHumansLipid PeroxidationMiceReperfusion InjuryIronSpermine

Identifiers

PMID42236947

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.