Evidence map›Paper›PMID 42236892›Full record

ArticleNpj biological timing and sleep2026

Perivascular space, brain functional connectivity and sleep: a healthy aging population study.

Nien-Chu Shih, Joey A Contreras, Wendy J Mack, Jeiran Choupan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Npj biological timing and sleep, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Nien-Chu ShihLaboratory of Neuro Imaging, USC Mark and Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Joey A ContrerasAlzheimer's Disease Cooperative Study (ADCS), University of California San Diego, La Jolla, CA, USA.
Wendy J MackDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Jeiran ChoupanLaboratory of Neuro Imaging, USC Mark and Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. choupan@usc.edu.

Funding

Structural and diffusion changes of perivascular space in aging, cognitive decline and Alzheimer's diseaseR01AG070825 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHOUPAN, JEIRAN · 2021 to 2025
$4.1M
High Capacity, High Performance Storage System for NeuroscienceS10OD032285 · OD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TOGA, ARTHUR W · 2022 to 2022
$1.7M
Mapping human brain perivascular space in lifespan using human connectome project dataRF1MH123223 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHOUPAN, JEIRAN · 2020 to 2020
$1.3M
NIA NIH HHS R01AG070825NIH HHS S10OD032285NIMH NIH HHS RF1MH123223
6 · The paper itself

Abstract

Perivascular space (PVS) surrounds cortical perforating vessels as part of the brain clearance system. Sleep affects both brain clearance and functional connectivity (FC), but impacts of PVS on FC remains unclear. We utilized T1-W and resting state-fMRI data, Pittsburgh Sleep Quality Index, and NIH cognitive tests from 512 health aging (HCP-Aging). Basal ganglia (BG)-PVS was positively correlated with FC in the right anterior medial temporal gyrus (aMTG) and right temporal regions, while centrum-semiovale (CSO)-PVS was positively correlated with FC in the left hippocampus and right frontal regions. In early middle-aged, increased CSO-PVS showed higher hippocampal FC and better cognition. Individuals with longer time spent in bed had larger BG-PVS linked to higher FC in the right aMTG. Additionally, older adults with better sleep quality had larger BG-PVS linked to higher FC in the right aMTG. This suggests that PVS morphology may reflect changes in neural connections involved in memory-related regions. This study is based on the same cohort as our previous work; however, it extends the investigation by incorporating functional connectivity analyses to provide novel insights beyond regional activity.

Identifiers

PMID42236892
PMCPMC13233977

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.