Evidence map›Paper›PMID 42236825›Full record

ArticleScientific reports2026

HuR-dependent expression of RyR2 contributes to calcium-mediated thermogenesis in murine brown adipocytes.

Adrienne R Guarnieri, Sarah R Anthony, Bo-Yao Wen, Mary E Seramur, Pooja Acharya, Daniel A Kasprovic, Katarina Benejova, Lindsey Lanzillotta, Rylie Gavin, Martin Benej and 1 more

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Adrienne R GuarnieriDepartment of Molecular Medicine and Therapeutics, The Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.
Sarah R AnthonyDepartment of Molecular Medicine and Therapeutics, The Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.
Bo-Yao WenDepartment of Molecular Medicine and Therapeutics, The Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.
Mary E SeramurDepartment of Molecular Medicine and Therapeutics, The Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.
Pooja AcharyaDepartment of Molecular Medicine and Therapeutics, The Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.
Daniel A KasprovicDepartment of Molecular Medicine and Therapeutics, The Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.
Katarina BenejovaDepartment of Molecular Medicine and Therapeutics, The Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.
Lindsey LanzillottaDivision of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, 45208, USA.
Rylie GavinDivision of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, 45208, USA.
Martin BenejDepartment of Molecular Medicine and Therapeutics, The Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.
Michael TranterDepartment of Molecular Medicine and Therapeutics, The Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA. Michael.Tranter@osumc.edu.

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Daniel G. Stover · 1985 to 2026
$132.3M
Understanding Cardiovascular Disease MechanismsT32HL125204 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Evangelia G Kranias, Jeffery D Molkentin · 2015 to 2026
$3.4M
Post-transcriptional control of adipose tissue gene expression as an endocrine mediator of cardiac pathologyR01HL158671 · NHLBI · UNIVERSITY OF CINCINNATI · PI Michael Tranter · 2022 to 2026
$3.1M
Leica Stellaris 8 Confocal MicroscopeS10OD030402 · OD · UNIVERSITY OF CINCINNATI · PI HONG, CHRISTIAN I · 2021 to 2021
$598k
American Heart Association 19TPA34910086American Heart Association 916812NCI NIH HHS P30 CA016058NHLBI NIH HHS R01 HL158671NHLBI NIH HHS R01-HL158671NHLBI NIH HHS T32 HL125204NHLBI NIH HHS T32-HL125204NIH HHS S10 OD030402
6 · The paper itself

Abstract

Several thermogenic pathways have been described in adipose tissue, including calcium-mediated thermogenesis in beige adipocytes. We have previously shown that adipocyte-specific deletion of the RNA binding protein human antigen R (HuR; Elavl1) results in thermogenic dysfunction. RNA sequencing revealed the downregulation of several calcium transport genes upon HuR deletion. The goal of this work was to define the HuR-dependent mechanisms of calcium driven thermogenesis in brown adipocytes. Brown adipose tissue (BAT)-specific HuR-deletion (BAT-HuR

Indexed as

Adipocytes, BrownCalciumELAV-Like Protein 1Ryanodine Receptor Calcium Release ChannelThermogenesisAdipose Tissue, BrownAnimalsMaleMiceMice, KnockoutCalciumElavl1 protein, mouseELAV-Like Protein 1Ryanodine Receptor Calcium Release ChannelBrown adipose tissue (BAT)calciumHuman antigen R (HuR)Ryanodine Receptors (RyR)thermogenesis

Identifiers

PMID42236825
PMCPMC13473574

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.