Evidence map›Paper›PMID 42236660›Full record

ArticleDrug delivery and translational research2026

Advancing transdermal drug delivery using translational data and mechanistic based modeling.

John P Rose, Nisha Shrestha, Yogesh Prakash Patil, Jeffrey S Tan, Reshma Bharadwaj, J Anand Subramony

Abstract read
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Article in Drug delivery and translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

John P RoseEli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, 46285, USA.
Nisha ShresthaEli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, 46285, USA.
Yogesh Prakash PatilEli Lilly and Company, Embassy Tech Village, Lilly Bengaluru, Bengaluru, 560103, India.
Jeffrey S TanEli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, 46285, USA.
Reshma BharadwajEli Lilly and Company, Embassy Tech Village, Lilly Bengaluru, Bengaluru, 560103, India.
J Anand SubramonyEli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, 46285, USA. anand.subramony@lilly.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transdermal drug delivery systems (TDDS) offer patient-centric advantages as drug dosage forms, but candidate selection for transdermal within early discovery remains challenging due to high attrition rates (> 40%) and limited predictive screening methodologies. This work introduces a mechanistic, data-driven in silico model to accelerate candidate selection for transdermal drug delivery, leveraging translational data from four approved products. The model simulates passive diffusive transport across the epidermis, focusing on two critical parameters: the partition coefficient between patch and skin (K

Indexed as

diffusion coefficientmodelingpartition coefficientstratum corneumtransdermal delivery

Identifiers

PMID42236660

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.