ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2026
Next-generation sequencing using a targeted gene panel in advanced solid tumors: five years of experience from an Italian referral institution.
Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
Abstract
aimsNext generation sequencing (NGS) represents the "holy grail" for the diagnostic algorithm for advanced solid tumors. In our experience, we commonly use our customized DNA-based NGS panel (namely, SiRe®). The aim of this study was to assess the efficiency of our customized DNA-based NGS panel in detecting molecular alterations in both tissue and liquid biopsy samples.
methodsWe retrospectively retrieved molecular data from our electronic archives of advanced stage solid tumor cases tested by our DNA-based NGS approach from January 2018 to December 2022. Almost all samples (2045/2173, 94.1%), including liquid biopsies, were analyzed with our DNA-based NGS approach. We also retrieved all relevant molecular data on other tested biomarkers.
resultsA total of n = 2173 advanced stage solid tumor patients were tested. Overall, at least one DNA-based alteration was detected in 52.7%, 66.6%, 87.6%, 68.8%, 46.7% of NSCLC ADC, CRC, GIST, melanoma, and breast cancer cases.
conclusionsThe present study has provided a real-world practice experience on the efficiency of applying DNA-based NGS analysis to both tissue and liquid biopsy samples in detecting actionable mutations in advanced stage solid tumor patients.
Indexed as
Identifiers
42236654What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.