Evidence map›Paper›PMID 42236624›Full record

ArticleJournal of molecular modeling2026

Predicting an intrinsic conformational twist in Card1: an in silico study.

Guodong Hu, Zhenshen Bao, Haiting Dong, Chongzheng Hao, Chengfei Cai, Jin Qian

Abstract read
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Article in Journal of molecular modeling, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Guodong HuJiangsu Key Laboratory of Intelligent Drug Screening and Repositioning (TZU), School of Information Engineering, Taizhou University, Taizhou, 225300, China. hugd@tzu.edu.cn.
Zhenshen BaoJiangsu Key Laboratory of Intelligent Drug Screening and Repositioning (TZU), School of Information Engineering, Taizhou University, Taizhou, 225300, China.
Haiting DongJiangsu Key Laboratory of Intelligent Drug Screening and Repositioning (TZU), School of Information Engineering, Taizhou University, Taizhou, 225300, China.
Chongzheng HaoJiangsu Key Laboratory of Intelligent Drug Screening and Repositioning (TZU), School of Information Engineering, Taizhou University, Taizhou, 225300, China.
Chengfei CaiJiangsu Key Laboratory of Intelligent Drug Screening and Repositioning (TZU), School of Information Engineering, Taizhou University, Taizhou, 225300, China.
Jin QianJiangsu Key Laboratory of Intelligent Drug Screening and Repositioning (TZU), School of Information Engineering, Taizhou University, Taizhou, 225300, China. qianjin@tzu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextType III CRISPR systems use cA

methodsAll simulations were performed using the AMBER24 package. For the all-atom model, the AMBER ff19SB force field was used. For the coarse-grained model, the SIRAH force field was employed. GaMD simulations were applied using a total potential energy boosting. The large conformational changes were investigated by coarse-grained MD simulations. The CPPTRAJ program was used to calculate structural parameters-including distances, native contacts, RMSD, secondary structure, PCA, angles, and dihedral angles.

Indexed as

CARD Signaling Adaptor ProteinsBinding SitesComputer SimulationHydrogen BondingModels, MolecularMolecular Dynamics SimulationProtein BindingProtein ConformationProtein DomainsCARD Signaling Adaptor ProteinsCard1 proteinCoarse grain modelConformational changeMolecular dynamics simulations

Identifiers

PMID42236624

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.