ArticleNature computational science2026
MetaSTAARlite: an all-in-one tool for biobank-scale whole-genome sequencing meta-analysis.
Article in Nature computational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- MetaSTAARlite: an all-in-one tool for biobank-scale whole-genome sequencing meta-analysis.Nature computational science · 2026Article
- An empirical Bayes framework for burden and dispersion association tests helps prioritize rare variants associated with Alzheimer's disease.medRxiv : the preprint server for health sciences · 2026Article
- FAVOR 2.0: A reengineered functional annotation of variants online resource for interpreting genomic variation.Nucleic acids research · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Biobank-scale sequencing studies have enabled the analysis of rare variants contributing to complex traits. Here we introduce MetaSTAARlite, a scalable and resource-efficient summary statistics-based pipeline for functionally informed rare-variant meta-analysis in both the coding and noncoding genome, bypassing the data-sharing restrictions of pooled analysis using individual-level data across multiple biobanks. Using the sequencing data of the UK Biobank and the All of Us Research Program, we demonstrate that MetaSTAARlite's computation time, memory and storage requirements scale linearly with sample size, while producing results highly concordant with those of a pooled analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.