Evidence map›Paper›PMID 42236478›Full record

ArticleNature communications2026

In vivo dynamic hotspot-enhanced Raman spectroscopy via reconfigurable swarming nanoprobes.

Dongfang Zhao, Hui Chen, Dongdong Jin, Hanyu Cao, Xiaojia Liu, Yong Wang, Xingzhou Du, Jiangfan Yu, Jinhong Guo, Li Zhang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dongfang Zhao *Sauvage Laboratory for Smart Materials, School of Integrated Circuits, Harbin Institute of Technology (Shenzhen), Shenzhen, China.
Hui Chen *School of Science and Engineering, The Chinese University of Hong Kong (Shenzhen), Shenzhen, China.
Dongdong Jin *Sauvage Laboratory for Smart Materials, School of Integrated Circuits, Harbin Institute of Technology (Shenzhen), Shenzhen, China. jindongdong@hit.edu.cn.ORCID http://orcid.org/0000-0003-4833-538X
Hanyu CaoSchool of Sensing Science and Engineering, Shanghai Jiao Tong University, Shanghai, China.
Xiaojia LiuSauvage Laboratory for Smart Materials, School of Integrated Circuits, Harbin Institute of Technology (Shenzhen), Shenzhen, China.
Yong WangKey Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing, China.
Xingzhou DuInstitute of Robotics and Intelligent Systems, Dalian University of Technology, Dalian, China.ORCID http://orcid.org/0000-0002-8526-7286
Jiangfan YuSchool of Science and Engineering, The Chinese University of Hong Kong (Shenzhen), Shenzhen, China.ORCID http://orcid.org/0000-0002-7981-6744
Jinhong GuoSchool of Sensing Science and Engineering, Shanghai Jiao Tong University, Shanghai, China.ORCID http://orcid.org/0000-0003-2659-3150
Li ZhangDepartment of Mechanical and Automation Engineering, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China. lizhang@cuhk.edu.hk.ORCID http://orcid.org/0000-0003-1152-8962
Xing MaSauvage Laboratory for Smart Materials, School of Integrated Circuits, Harbin Institute of Technology (Shenzhen), Shenzhen, China. maxing@hit.edu.cn.ORCID http://orcid.org/0000-0002-2248-4806

Funding

National Natural Science Foundation of China (National Science Foundation of China) 52472280Shenzhen Science and Technology Innovation Commission KJZD20231023100302006Shenzhen Science and Technology Innovation Commission RCJC20231211090000001; GXWD20231129101105001
6 · The paper itself

Abstract

Surface-enhanced Raman spectroscopy (SERS) offers exceptional sensitivity but faces a critical trade-off in living systems: rigid substrates lack biological adaptability, while colloidal nanoprobes suffer from poor signal reproducibility. Herein, we present a bioadaptive SERS platform using magnetically guided swarming nanoprobes. These probes integrate a magnetic core, plasmonic gold/silver layers, and a biocompatible silica coating, enabling programmable assembly under magnetic fields into chain-like nanostructures with interparticle gap-dependent hotspots, followed by coordinated reconfiguration into dynamically stable swarms. Multiphysics simulations reveal that cyclic assembly-disassembly generates transient electromagnetic hotspots while inducing convective flows to actively recruit analytes. This dual mechanism achieves reproducible enhancement factors exceeding 2.9×10

Indexed as

Metal NanoparticlesNanostructuresSpectrum Analysis, RamanAnimalsGoldRabbitsSilicon DioxideSilverGoldSilicon DioxideSilver

Identifiers

PMID42236478
PMCPMC13396500

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.