Evidence map›Paper›PMID 42236419›Full record

ArticleTrends in microbiology2026

LpxC activity regulation: An emerging paradigm for controlling lipopolysaccharide synthesis.

Rajkanwar Nathawat, Chang Liu, Wei Mi

Abstract read
In one paragraph

Article in Trends in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Rajkanwar NathawatDepartment of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA.
Chang LiuDepartment of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA.
Wei MiDepartment of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: wei.mi@yale.edu.

Funding

Understanding how membrane composition directs membrane protein structure and functionRM1GM149406 · NIGMS · YALE UNIVERSITY · PI Joel Adam Butterwick, KATHRYN M FERGUSON · 2023 to 2026
$8.4M
Molecular Mechanisms of the Type I Secretion System from Bacterial PathogensR01GM137068 · NIGMS · YALE UNIVERSITY · PI MI, WEI · 2021 to 2025
$1.9M
NIGMS NIH HHS R01 GM137068NIGMS NIH HHS RM1 GM149406
6 · The paper itself

Abstract

Lipopolysaccharide (LPS) levels in Gram-negative bacteria are primarily controlled by LpxC, a deacetylase catalyzing the committed step of LPS synthesis. Studies of LPS regulation have long focused on controlling LpxC abundance. However, recent findings on the allosteric regulation of LpxC activity suggest a broader framework for LPS synthesis control.

Indexed as

AmidohydrolasesGene Expression Regulation, BacterialGram-Negative BacteriaLipopolysaccharidesAllosteric RegulationBacterial ProteinsAmidohydrolasesBacterial ProteinsLipopolysaccharidesUDP-3-O-acyl-N-acetylglucosamine deacetylaseallosteric controlbacterial outer membranelipopolysaccharide (LPS) synthesisLpxC activity

Identifiers

PMID42236419
PMCPMC13240662

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.