ArticleMagnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine2026
Measuring Brain Stiffness in Normal Adults According to Age and Sex Using Virtual MR Elastography: A Preliminary Study.
Article in Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeAssessing brain stiffness alterations associated with normal aging, sex-related differences, and regional variations is important from clinical perspective. The study aimed to investigate the changes in brain stiffness according to age and sex using virtual magnetic resonance elastography (vMRE), a noninvasive and novel technique based on diffusion-weighted imaging (DWI).
methodsWe retrospectively reviewed 96 adults (31-80 years, 51 men and 45 women) who underwent MRI as part of routine medical examinations. The shifted apparent diffusion coefficient was calculated from DWI (b = 200 and 1500 sec/mm
resultsBrain stiffness exhibited regional differences, with higher shear modulus values observed in deep structures (thalamus and basal ganglia) compared to that in lobar regions (P < 0.01). Among lobar areas, the occipital lobe had the highest stiffness, whereas the temporal lobe had the lowest (P < 0.01). Linear regression revealed a significant negative correlation between age and brain stiffness (-0.06%/year, R
conclusionOur findings suggest that vMRE can effectively measure the elastic properties of the brain. Brain stiffness decreases with age, but these changes vary across different regions.
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