Evidence map›Paper›PMID 42236212›Full record

ArticleThe Journal of veterinary medical science2026

Expression of aquaporin 3 in squamous cell carcinoma in dogs and cats.

Hiroko Sonoda, Yoshiki Taniguchi, Naruki Fujimoto, Yoshiki Higashijima, Toshiyuki Matsuzaki, Takuya Hirai, Teruo Itoh, Kazuyuki Uchida, Masahiro Ikeda

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In one paragraph

Article in The Journal of veterinary medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hiroko SonodaDepartment of Veterinary Pharmacology, University of Miyazaki, Miyazaki, Japan.
Yoshiki TaniguchiDepartment of Veterinary Pharmacology, University of Miyazaki, Miyazaki, Japan.
Naruki FujimotoDepartment of Veterinary Pharmacology, University of Miyazaki, Miyazaki, Japan.
Yoshiki HigashijimaInstitute for Promotion of Tenure Track, University of Miyazaki, Miyazaki, Japan.
Toshiyuki MatsuzakiDepartment of Anatomy and Cell Biology, Gunma University Graduate School of Medicine, Gunma, Japan.
Takuya HiraiDepartment of Veterinary Pathology, University of Miyazaki, Miyazaki, Japan.
Teruo ItohDivision of Animal Medical Research, Miyazaki, Japan.
Kazuyuki UchidaLaboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Masahiro IkedaDepartment of Veterinary Pharmacology, University of Miyazaki, Miyazaki, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aquaporins (AQPs) are membrane proteins that facilitate the transport of small molecules such as water, glycerol, and urea. In mammals, 13 AQP isoforms (AQP0 to AQP12) exhibit tissue-specific expression. Over the past two decades, aquaporins (AQPs) have received considerable attention for their role in tumor biology. Squamous cell carcinoma (SCC) originates from stratified squamous cells and commonly affects the skin and oral cavity. SCC is prevalent in dogs and cats; however, no studies have reported an association between SCC and AQPs in these species. This study investigated the immunohistochemical expression of AQP1, AQP3, AQP5, E-cadherin, and Ki-67 in cutaneous and oral SCCs of dogs and cats. AQP1 and AQP5 were not expressed in tumor cells. In contrast, AQP3 and E-cadherin localized to the plasma membrane, primarily within island-like structures in both cutaneous and oral SCCs. Ki-67-positive cells appeared in small group and cord structures within tumor regions exhibiting reduced AQP3 expression. Therefore, AQP3 expression may be down-regulated in malignant tumor cells in SCCs of dogs and cats. These findings indicate that AQP3 may serve as a novel biomarker for assessing malignancy in SCCs of dogs and cats.

Indexed as

Aquaporin 3Carcinoma, Squamous CellCat DiseasesDog DiseasesMouth NeoplasmsSkin NeoplasmsAnimalsBiomarkers, TumorCadherinsCatsDogsGene Expression Regulation, NeoplasticImmunohistochemistryKi-67 AntigenAquaporin 3Biomarkers, TumorCadherinsKi-67 Antigenaquaporin 3catdogKi-67squamous cell carcinoma

Identifiers

PMID42236212
PMCPMC13500385

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.