Evidence map›Paper›PMID 42235998›Full record

ArticleRNA (New York, N.Y.)2026

Onconeural antigen NOVA1 dysregulates RNA alternative splicing in breast cancer.

Daniel F Moakley, Ye Wang, Chaolin Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RNA (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Daniel F Moakley *Department of Systems Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.
Ye Wang *Department of Systems Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.
Chaolin ZhangDepartment of Systems Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA cz2294@columbia.edu.ORCID http://orcid.org/0000-0002-8310-7537

Funding

Complexity and evolution of splicing-regulatory networksR35GM145279 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Chaolin Zhang · 2022 to 2026
$4.6M
Computational and experimental approaches to decode domain-specific protein-RNA interactionsR01HG014077 · NHGRI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Lei Wang, Chaolin Zhang · 2026 to 2026
$3.2M
RNA Regulatory Networks in Neuronal Cell Type Diversity and FunctionR01NS125018 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Chaolin Zhang · 2022 to 2026
$3.0M
ADVANCED GRADUATE TRAINING PROGRAM IN NEUROBIOLOGY & BEHAVIORT32NS064928 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HENGST, ULRICH · 2010 to 2024
$3.0M
NHGRI NIH HHS R01 HG014077NIGMS NIH HHS R35 GM145279NINDS NIH HHS R01 NS125018NINDS NIH HHS T32 NS064928
6 · The paper itself

Abstract

The neuron-specific splicing factor NOVA1 was first discovered as an onconeural antigen ectopically expressed in breast tumors, causing rare autoimmune reactions and paraneoplastic neurological disorders (PNDs). The PND model suggests a plausible role of the tumor antigen expression in tumor suppression, whereas it has emerged that NOVA exhibits oncogenic activity in cell-based models. Whether NOVA mediates alternative splicing (AS) in native cancer remains unknown. Here we examine the AS profiles of breast invasive carcinoma (BRCA) tumor samples and demonstrate that aberrant

Indexed as

Alternative SplicingAntigens, NeoplasmBreast NeoplasmsRNA-Binding ProteinsCell Line, TumorFemaleGene Expression Regulation, NeoplasticHumansNeuro-Oncological Ventral AntigenAntigens, NeoplasmNeuro-Oncological Ventral AntigenNOVA1 protein, humanRNA-Binding Proteinsalternative splicingcancerNOVA1RNA-binding proteins

Identifiers

PMID42235998
PMCPMC13374512

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.