ArticleNeuron2026
A hypothalamic circuit for anticipating future changes in energy balance.
Article in Neuron, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types.Cell reports · 2026Article
- A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types.Research square · 2025Article
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10 authors.
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Abstract
AgRP neurons cause hunger, the drive to seek and consume food. Their activation by fasting is key for survival and is thought to be triggered by feedback when energy stores are low. However, we know that environmental cues can also regulate AgRP neurons since cues that predict future food intake rapidly inhibit AgRP neurons, but is the converse true: can the prediction of future fasting rapidly activate AgRP neurons? Here, we show in mice that such rapid fasting activation of AgRP neurons does occur. This rapid activation is driven by excitatory input from paraventricular hypothalamic (PVH) neurons expressing Sim2, which are bidirectionally sensitive to predictions of future energy state. Thus, cognitively processed contextual information conveyed by PVH
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