Evidence map›Paper›PMID 42235132›Full record

ArticleAnais brasileiros de dermatologia

Increased risk of atrial fibrillation among patients with bullous pemphigoid: a nationwide cohort study in Taiwan.

Tai-Li Chen, Wan-Ting Huang, Chen-Yi Wu, Ching-Hui Loh, Huei-Kai Huang, Chi Ching-Chi

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Article in Anais brasileiros de dermatologia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Tai-Li ChenDepartment of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Dermatology, School of Medicine, National Yang Ming Chao Tung University, Taipei, Taiwan.
Wan-Ting HuangCenter for Clinical Epidemiology and Biostatistics, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Chen-Yi WuDepartment of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Dermatology, School of Medicine, National Yang Ming Chao Tung University, Taipei, Taiwan; Department of Public Health, College of Medicine, National Yang Ming Chao Tung University, Taipei, Taiwan.
Ching-Hui LohCenter for Aging and Health, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan; School of Medicine, College of Medicine, Tzu Chi University, Hualien, Taiwan.
Huei-Kai HuangCenter for Clinical Epidemiology and Biostatistics, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan; School of Medicine, College of Medicine, Tzu Chi University, Hualien, Taiwan; Department of Family Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Chi Ching-ChiDepartment of Dermatology, Chang Gung Memorial Hospital, Linkou Main Branch, Taoyuan, Taiwan; School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address: chingchi@cgmh.org.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBullous Pemphigoid (BP) and Atrial Fibrillation (AF) share common underlying mechanisms involving chronic inflammation, but their relationship was unclear.

objectiveTo assess the risk of incident AF in individuals with BP.

methodsThis nationwide cohort study utilized Taiwan's National Health Insurance Research Database from 2011 to 2019. Adults newly diagnosed with BP were identified and initially matched by age and sex to controls without BP. Stabilized inverse probability weighting was applied to balance baseline characteristics between cohorts. Cox proportional hazards models were used to estimate Hazard Ratios (HRs) and 95% Confidence Intervals (95% CIs) for incident AF. Subgroup analyses were performed by age and sex, along with several sensitivity analyses.

resultsDuring the follow-up period, AF occurred in 510 of the 9,554 patients in the BP group and 1,902 of the 52,015 individuals in the non-BP group, corresponding to an incidence of 15.03 and 7.99 per 1,000 person-years, respectively. BP was associated with an increased risk of incident AF (HR 1.83; 95% CI 1.66-2.02). This association persisted across analyses stratified by age and sex. The findings were consistent across multiple sensitivity analyses. STUDY LIMITATIONS: The unavailability of data on potential confounders such as lifestyle factors (smoking, alcohol, obesity) and disease severity.

conclusionsBP is linked to a heightened risk of AF. Prompt recognition of AF and timely cardiology referrals may be warranted in BP patients presenting with suggestive symptoms.

Indexed as

Atrial FibrillationPemphigoid, BullousAdultAgedAged, 80 and overCohort StudiesFemaleHumansIncidenceMaleMiddle AgedProportional Hazards ModelsRisk FactorsTaiwanAtrial fibrillationBullous pemphigoidCohort study

Identifiers

PMID42235132
PMCPMC13265673

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.