Observational studyAnais brasileiros de dermatologia
Squamous cell carcinoma in chronic lesions of recalcitrant chromoblastomycosis. Study of ten patients treated at the Dermatological Center of Yucatán, Mexico.
Observational study in Anais brasileiros de dermatologia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundChromoblastomycosis is a chronic granulomatous fungal infection of the skin and subcutaneous tissue caused by dematiaceous fungi of the family Herpotrichiellaceae. It is considered an occupational disease, predominantly affecting male agricultural workers, with a worldwide distribution, especially in tropical and subtropical regions. Fonsecaea pedrosoi accounts for approximately 90% of reported cases.
objectiveTo describe the etiological agents, clinical features, and major complications associated with chromoblastomycosis.
methodsA retrospective, descriptive, and observational study presenting a case series was conducted, focusing on the pathogenesis, clinical presentation, disease course, and reported complications of chromoblastomycosis.
resultsA total of 131 cases of chromoblastomycosis were documented; 10 patients (7.65%) developed squamous cell carcinoma. The mean age was 65.8-years, and the mean disease duration prior to malignant transformation was 17.4-years. The most frequently affected site was the upper limb (70%), followed by the lower limb (20%) and the trunk (10%). STUDY LIMITATIONS: The descriptive nature of this review limits causal inference and precise estimation of malignant transformation rates.
conclusionChromoblastomycosis is a chronic, polymorphic cutaneous infection often diagnosed late, leading to long-standing disease and disabling sequelae. Malignant transformation to squamous cell carcinoma represents one of its most severe complications and may occur even in residual scars. Early diagnosis and prolonged follow-up are essential to reduce morbidity and prevent malignant progression.
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